A new sesquiterpene pyridine alkaloid, emarginatine Β  has been isolated, along with maytansine , from Maytenus emarginata. Emarginatine Β showed potent cytotoxicity against human KB cells (ED50 = 0.4 μg/ml). Spectral correlations established its structure as a 9-benzoate and C-8 epimer of emarginatine A . The conformational aspect of the latter compound was elucidated by nmr studies, including the use of 2D-nmr techniques and difference nOe methods.
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