Antitumor agents, 112.1 emarginatine Β, a novel potent cytotoxic sesquiterpene pyridine alkaloid from maytenus emarginata

Yao Haur Kuo, Chung Hsiung Chen, Li Ming Yang Kuo, Ming Lu King, Tian Shung Wu, Mitsumasa Haruna, Kuo Hsiung Lee

研究成果: Article同行評審

42 引文 斯高帕斯(Scopus)

摘要

A new sesquiterpene pyridine alkaloid, emarginatine Β [2] has been isolated, along with maytansine [3], from Maytenus emarginata. Emarginatine Β showed potent cytotoxicity against human KB cells (ED50 = 0.4 μg/ml). Spectral correlations established its structure as a 9-benzoate and C-8 epimer of emarginatine A [1]. The conformational aspect of the latter compound was elucidated by nmr studies, including the use of 2D-nmr techniques and difference nOe methods.

原文English
頁(從 - 到)422-428
頁數7
期刊Journal of Natural Products
53
發行號2
DOIs
出版狀態Published - 1990

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 分子醫學
  • 藥理
  • 藥學科學
  • 藥物發現
  • 補充和替代醫學
  • 有機化學

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