Antitumor agents, 119. Kansuiphorins A and B, two novel antileukemic diterpene esters from euphorbia kansui

Tian Shung Wu, Yuh Meei Lin, Mitsumasa Haruna, De Ji Pan, Tetsuro Shingu, Yuh Pan Chen, Hong Yen Hsu, Tatsuhiko Nakano, Kuo Hsiung Lee

研究成果: Article同行評審

99 引文 斯高帕斯(Scopus)

摘要

The extract of the roots of Euphorbia kansui, which has been widely used in Chinese folk medicine for the treatment of cancer, demonstrated antileukemic activity against the P-388 lymphocytic leukemia in mice. Bioassay-directed fractionation of the active extract led to the isolation and characterization of two novel antileukemic diterpene esters, kansuiphorin A [1] [13-hydroxyingenol-3-<2,3-dimethylbutanoate)-13-dodecanoate-20-hexadecanoate] and kansuiphorin B [2] [6,7-epoxy-13-hydroxyingenol-3-(2,3-dimethylbutanoate)-13-dodecanoate-20-hexadecanoate], whose structures were established from spectral evidence and chemical transformation. Kansuiphorins A and B demonstrated potent antileukemic activity with T/CS176 and 177% at 0.1 and 0.5 mg/kg, respectively. The selectivity of kansuiphorin A, which inhibits the growth of particular cell types within the disease-oriented human cancer cell line panels, is discussed.

原文English
頁(從 - 到)823-829
頁數7
期刊Journal of Natural Products
54
發行號3
DOIs
出版狀態Published - 1991 五月 1

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 分子醫學
  • 藥理
  • 藥學科學
  • 藥物發現
  • 補充和替代醫學
  • 有機化學

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