Apoptotic and nonapoptotic activities of pterostilbene against cancer

Rong Jane Chen, Hsiao Che Kuo, Li Hsin Cheng, Yu Hsuan Lee, Wen Tsan Chang, Bour Jr Wang, Ying Jan Wang, Hung Chi Cheng

研究成果: Review article

6 引文 (Scopus)

摘要

Cancer is a major cause of death. The outcomes of current therapeutic strategies against cancer often ironically lead to even increased mortality due to the subsequent drug resistance and to metastatic recurrence. Alternative medicines are thus urgently needed. Cumulative evidence has pointed out that pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene, PS) has excellent pharmacological benefits for the prevention and treatment for various types of cancer in their different stages of progression by evoking apoptotic or nonapoptotic anti-cancer activities. In this review article, we first update current knowledge regarding tumor progression toward accomplishment of metastasis. Subsequently, we review current literature regarding the anti-cancer activities of PS. Finally, we provide future perspectives to clinically utilize PS as novel cancer therapeutic remedies. We, therefore, conclude and propose that PS is one ideal alternative medicine to be administered in the diet as a nutritional supplement.

原文English
文章編號287
期刊International journal of molecular sciences
19
發行號1
DOIs
出版狀態Published - 2018 一月 18

指紋

Medicine
cancer
Nutrition
Tumors
Neoplasms
medicine
progressions
Complementary Therapies
Pharmaceutical Preparations
diets
mortality
supplements
metastasis
death
pterostilbene
Drug Resistance
drugs
tumors
Cause of Death
Therapeutics

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

引用此文

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title = "Apoptotic and nonapoptotic activities of pterostilbene against cancer",
abstract = "Cancer is a major cause of death. The outcomes of current therapeutic strategies against cancer often ironically lead to even increased mortality due to the subsequent drug resistance and to metastatic recurrence. Alternative medicines are thus urgently needed. Cumulative evidence has pointed out that pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene, PS) has excellent pharmacological benefits for the prevention and treatment for various types of cancer in their different stages of progression by evoking apoptotic or nonapoptotic anti-cancer activities. In this review article, we first update current knowledge regarding tumor progression toward accomplishment of metastasis. Subsequently, we review current literature regarding the anti-cancer activities of PS. Finally, we provide future perspectives to clinically utilize PS as novel cancer therapeutic remedies. We, therefore, conclude and propose that PS is one ideal alternative medicine to be administered in the diet as a nutritional supplement.",
author = "Chen, {Rong Jane} and Kuo, {Hsiao Che} and Cheng, {Li Hsin} and Lee, {Yu Hsuan} and Chang, {Wen Tsan} and Wang, {Bour Jr} and Wang, {Ying Jan} and Cheng, {Hung Chi}",
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Apoptotic and nonapoptotic activities of pterostilbene against cancer. / Chen, Rong Jane; Kuo, Hsiao Che; Cheng, Li Hsin; Lee, Yu Hsuan; Chang, Wen Tsan; Wang, Bour Jr; Wang, Ying Jan; Cheng, Hung Chi.

於: International journal of molecular sciences, 卷 19, 編號 1, 287, 18.01.2018.

研究成果: Review article

TY - JOUR

T1 - Apoptotic and nonapoptotic activities of pterostilbene against cancer

AU - Chen, Rong Jane

AU - Kuo, Hsiao Che

AU - Cheng, Li Hsin

AU - Lee, Yu Hsuan

AU - Chang, Wen Tsan

AU - Wang, Bour Jr

AU - Wang, Ying Jan

AU - Cheng, Hung Chi

PY - 2018/1/18

Y1 - 2018/1/18

N2 - Cancer is a major cause of death. The outcomes of current therapeutic strategies against cancer often ironically lead to even increased mortality due to the subsequent drug resistance and to metastatic recurrence. Alternative medicines are thus urgently needed. Cumulative evidence has pointed out that pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene, PS) has excellent pharmacological benefits for the prevention and treatment for various types of cancer in their different stages of progression by evoking apoptotic or nonapoptotic anti-cancer activities. In this review article, we first update current knowledge regarding tumor progression toward accomplishment of metastasis. Subsequently, we review current literature regarding the anti-cancer activities of PS. Finally, we provide future perspectives to clinically utilize PS as novel cancer therapeutic remedies. We, therefore, conclude and propose that PS is one ideal alternative medicine to be administered in the diet as a nutritional supplement.

AB - Cancer is a major cause of death. The outcomes of current therapeutic strategies against cancer often ironically lead to even increased mortality due to the subsequent drug resistance and to metastatic recurrence. Alternative medicines are thus urgently needed. Cumulative evidence has pointed out that pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene, PS) has excellent pharmacological benefits for the prevention and treatment for various types of cancer in their different stages of progression by evoking apoptotic or nonapoptotic anti-cancer activities. In this review article, we first update current knowledge regarding tumor progression toward accomplishment of metastasis. Subsequently, we review current literature regarding the anti-cancer activities of PS. Finally, we provide future perspectives to clinically utilize PS as novel cancer therapeutic remedies. We, therefore, conclude and propose that PS is one ideal alternative medicine to be administered in the diet as a nutritional supplement.

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DO - 10.3390/ijms19010287

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