TY - GEN
T1 - Application of gold nanoparticles for enhanced photo-thermal therapy of urothelial carcinoma
AU - Wu, Y. J.
AU - Chen, C. H.
AU - Chang, H. S.W.
AU - Chen, W. C.
AU - Jason Chen, J. J.
PY - 2011
Y1 - 2011
N2 - The aim of this study is to utilize photothermal therapy (PTT) to treat urothelial cancer using the unique optical properties- surface plasmon resonance of gold nanoparticles (GNPs). The GNPs were conjugated with anti-EGFR and anti- MUC7 antibody for tumor targeting. The conjugated GNPs were exposed under a green light laser (532nm) to produce the enough thermal energy and to kill the transitional cell carcinomas (TCC). Our results show that the cancer cells (MBT2, T24, 9202, 8301) were damaged at relatively lower energy (10 W/cm 2, 1.6 Hz with 300 ms) compared with the group without added GNPs. The damage was directly related to the applied laser energy and irradiation time. The therapeutic effects of superficial disease in situ by intravesical GNP agents instillation will be further performed in animal study of C3H mice. It is expected that the mini-invasive technology of PPT with GNPs not only reduces the high recurrence of TCC but also avoids the side effects from traditional chemotherapy.
AB - The aim of this study is to utilize photothermal therapy (PTT) to treat urothelial cancer using the unique optical properties- surface plasmon resonance of gold nanoparticles (GNPs). The GNPs were conjugated with anti-EGFR and anti- MUC7 antibody for tumor targeting. The conjugated GNPs were exposed under a green light laser (532nm) to produce the enough thermal energy and to kill the transitional cell carcinomas (TCC). Our results show that the cancer cells (MBT2, T24, 9202, 8301) were damaged at relatively lower energy (10 W/cm 2, 1.6 Hz with 300 ms) compared with the group without added GNPs. The damage was directly related to the applied laser energy and irradiation time. The therapeutic effects of superficial disease in situ by intravesical GNP agents instillation will be further performed in animal study of C3H mice. It is expected that the mini-invasive technology of PPT with GNPs not only reduces the high recurrence of TCC but also avoids the side effects from traditional chemotherapy.
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U2 - 10.1007/978-3-642-21729-6_98
DO - 10.1007/978-3-642-21729-6_98
M3 - Conference contribution
AN - SCOPUS:79960001589
SN - 9783642217289
T3 - IFMBE Proceedings
SP - 380
EP - 383
BT - 5th Kuala Lumpur International Conference on Biomedical Engineering 2011, BIOMED 2011
T2 - 5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, Held in Conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering, APCMBE 2011
Y2 - 20 June 2011 through 23 June 2011
ER -