Application of gold nanoparticles for enhanced photo-thermal therapy of urothelial carcinoma

Y. J. Wu, C. H. Chen, H. S.W. Chang, W. C. Chen, J. J. Jason Chen

研究成果: Conference contribution

1 引文 斯高帕斯(Scopus)

摘要

The aim of this study is to utilize photothermal therapy (PTT) to treat urothelial cancer using the unique optical properties- surface plasmon resonance of gold nanoparticles (GNPs). The GNPs were conjugated with anti-EGFR and anti- MUC7 antibody for tumor targeting. The conjugated GNPs were exposed under a green light laser (532nm) to produce the enough thermal energy and to kill the transitional cell carcinomas (TCC). Our results show that the cancer cells (MBT2, T24, 9202, 8301) were damaged at relatively lower energy (10 W/cm 2, 1.6 Hz with 300 ms) compared with the group without added GNPs. The damage was directly related to the applied laser energy and irradiation time. The therapeutic effects of superficial disease in situ by intravesical GNP agents instillation will be further performed in animal study of C3H mice. It is expected that the mini-invasive technology of PPT with GNPs not only reduces the high recurrence of TCC but also avoids the side effects from traditional chemotherapy.

原文English
主出版物標題5th Kuala Lumpur International Conference on Biomedical Engineering 2011, BIOMED 2011
頁面380-383
頁數4
DOIs
出版狀態Published - 2011
事件5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, Held in Conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering, APCMBE 2011 - Kuala Lumpur, Malaysia
持續時間: 2011 六月 202011 六月 23

出版系列

名字IFMBE Proceedings
35 IFMBE
ISSN(列印)1680-0737

Other

Other5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, Held in Conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering, APCMBE 2011
國家/地區Malaysia
城市Kuala Lumpur
期間11-06-2011-06-23

All Science Journal Classification (ASJC) codes

  • 生物工程
  • 生物醫學工程

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