Application of Lanthanide Shift Reagent to the 1H-NMR Assignments of Acridone Alkaloids

Sio Hong Lam, Hsin Yi Hung, Ping Chung Kuo, Daih Huang Kuo, Fu An Chen, Tian Shung Wu

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

This study investigates the application of the paramagnetic shift reagent tris(dipivaloylmethanato)-europium(III) in NMR spectral studies of permethoxyacridone alkaloids (1-3) and pyranoacridone alkaloids (4-6). The induced chemical shifts (∆δ) of all protons were observed for the same molecule, and were compared to deduce the positions resulting from the distance nearby the Eu(dpm)3. Assignment of the H-2, H-4 and H-8 of polysubstituted acridones could be distinguished based on the least-squares method of lanthanide-induced shifts plotted against the mole ratios of Eu(dpm)3 to the substrate. The developed method is not only potentially useful for determining the planar structures of polysubstituted compounds, such as acridones, anthraquinones, xanthones, flavonoids, and phenanthrenes, but also applicable for their stereochemistry.

原文English
期刊Molecules (Basel, Switzerland)
25
發行號22
DOIs
出版狀態Published - 2020 11月 17

All Science Journal Classification (ASJC) codes

  • 分析化學
  • 化學(雜項)
  • 分子醫學
  • 藥學科學
  • 藥物發現
  • 物理與理論化學
  • 有機化學

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