Application of standardized proportional mortality ratio to the assessment of health risk in relatively healthy populations: Using a study of cancer risk in telecommunication workers with excess exposure to acid mists as an example

Ying Fong Ker, Perng Jy Tsai, How Ran Guo

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)

摘要

When a study population is relatively healthy, such as an occupational population, epi-demiological studies are likely to underestimate risk. We used a case study on the cancer risk of workers with exposure to acid mists, a well-documented carcinogen, to demonstrate that using proportional mortality ratios (PMRs) is more appropriate than mortality ratios in assessing risk in terms of mortality. The study included 10,229 employees of a telecommunication company who worked in buildings with battery rooms. In these buildings, the battery rooms had the highest levels of sulfuric acid in the air (geometric mean = 10.7 µg/m3 ). With the general population in Taiwan as a reference, a decreased standardized mortality ratio (0.42, p < 0.01) from all causes combined, between 1 January 1985 and 31 December 1996, was observed, indicating a healthy worker effect. When we reanalyzed the data using standardized PMR, elevated risks were observed for all cancers combined (1.46, p = 0.01) and cancers of the digestive organs and peritoneum (1.61, p = 0.02), especially stomach cancer (2.94, p = 0.01). The results showed that PMR can detect increases in mortality when a study population is generally healthier than the comparison population and call for further studies on the possible carcinogenic effects of low-level acid mist exposures on the stomach.

原文English
文章編號9870
期刊International journal of environmental research and public health
18
發行號18
DOIs
出版狀態Published - 2021 9月

All Science Journal Classification (ASJC) codes

  • 污染
  • 公共衛生、環境和職業健康
  • 健康、毒理學和誘變

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