Arrhythmogenesis: a Roadblock to Cardiac Stem Cell Therapy

Yen Wen Liu, Chi Ting Su, Christopher Y.T. Yen, Li Jen Lin, Patrick C.H. Hsieh

研究成果: Review article

3 引文 斯高帕斯(Scopus)

摘要

Despite significant advances in the treatment of ischemic heart disease (IHD), it remains the leading cause of mortality worldwide. Undoubtedly, methods for regenerating the injured human heart are urgently needed, and whilst exciting progress has been made from utilizing stem cell therapy for cardiac regeneration, several major challenges still remain. In particular, one major safety issue is the occurrence of potentially life-threatening ventricular arrhythmias after cell therapy. Several drivers may be responsible for this, ranging from the potential inherent arrhythmogenicity of delivered stem cells to that of the underlying IHD. Therefore, it is imperative to thoroughly assess the risk-to-benefit ratio of such treatments prior to the clinical application. As such, despite the considerable progress made in stem cell therapy over the past decades, many obstacles still lie ahead.

原文English
文章編號61
期刊Current Treatment Options in Cardiovascular Medicine
18
發行號10
DOIs
出版狀態Published - 2016 十月 1

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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