Aspirin improves uterine blood flow in the peri-implantation period

Hong Chang Kuo, Chao Chin Hsu, Shan Tair Wang, Ko En Huang

研究成果: Article同行評審

26 引文 斯高帕斯(Scopus)


A prospective clinical study at the Infertility Clinic of National Cheng Kung University Hospital investigated the effect of aspirin on infertile women with impaired uterine perfusion. A total of 127 women with unexplained infertility or repeated failure with various assisted-conception techniques were enrolled. Uterine perfusion was assessed by Doppler ultrasound and classified as normal or impaired (pulsatility index <3.0 or ≤3.0, respectively). One-third (43/127) of the women were found to have impaired uterine perfusion during their menstrual cycles. Those with impaired uterine blood flow were given aspirin (100 mg/day) starting on day 3 of the next ovulatory cycle. Only 36 women completed both the screening and the aspirin-treated cycles. The pulsatility index was measured in the natural and aspirin-treated cycles in the same group of women and compared using repeated measures analyses of variance. A significant improvement in the uterine blood perfusion (p < 0.05) was detected on the day leutinizing hormone peaked and in the midluteal phase (peri-implantation period) of aspirin-treated cycles. Thus, the use of low-dose aspirin may improve uterine perfusion in women with unexplained infertility and impaired uterine blood flow.

頁(從 - 到)253-257
期刊Journal of the Formosan Medical Association
出版狀態Published - 1997 四月

All Science Journal Classification (ASJC) codes

  • 醫藥 (全部)


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