TY - JOUR
T1 - Assessment of human motoneuron
T2 - Afterhyperpolarization duration in health and disease
AU - Piotrkiewicz, Maria
AU - Kudina, Lydia
AU - Chen, Jia Jin Jason
AU - Hausmanowa-Petrusewicz, Irena
N1 - Funding Information:
In the majority of the experiments, the subject was comfortably seated in an armchair with the left forearm placed on a support assuring isometric muscle contrac-tions. The arm was positioned horizontally and the angle in the elbow was 90°. The wrist was supported by a cuff suspended from the ceiling. During the experiment the subject exerted a force by pressing a lever attached to a strain gauge. The signal of the force transducer and the required force level were displayed on the screen together with the electromyogram. The subject was provided with an auditory feedback of the MU discharges and was instructed to perform a series of 10-100 seconds constant force isometric contractions, keeping the MUs firing steadily. Between the consecu-tive recordings the subject was allowed to rest for 3-4 minutes. At the beginning of each experiment, the force of maximum voluntary contraction, MVC, was measured and used as a reference.
PY - 2012
Y1 - 2012
N2 - The results of the investigation of afterhyperpolarization (AHP) duration in normal aging and selected neuromuscular disorders are presented. This investigation yielded unexpected results: the AHP shortening in myogenic disease (DMD) and no significant difference from control values in neurogenic disease (ALS). However, introduction of age factor revealed novel aspects of the human ALS, which can be interpreted on the basis of the results obtained in a SOD1 mice, thus confirming usefulness of this animal model of ALS. In spastic patients the AHP was prolonged and the difference from the control AHP duration decreased with age and disease duration. Our results suggest that the match between temporal characteristics of the AHP of MN and of the twitch of its muscle unit is preserved during normal aging and in spasticity, but not in the DMD.
AB - The results of the investigation of afterhyperpolarization (AHP) duration in normal aging and selected neuromuscular disorders are presented. This investigation yielded unexpected results: the AHP shortening in myogenic disease (DMD) and no significant difference from control values in neurogenic disease (ALS). However, introduction of age factor revealed novel aspects of the human ALS, which can be interpreted on the basis of the results obtained in a SOD1 mice, thus confirming usefulness of this animal model of ALS. In spastic patients the AHP was prolonged and the difference from the control AHP duration decreased with age and disease duration. Our results suggest that the match between temporal characteristics of the AHP of MN and of the twitch of its muscle unit is preserved during normal aging and in spasticity, but not in the DMD.
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U2 - 10.1016/s0208-5216(12)70041-4
DO - 10.1016/s0208-5216(12)70041-4
M3 - Article
AN - SCOPUS:84867613494
SN - 0208-5216
VL - 32
SP - 43
EP - 61
JO - Biocybernetics and Biomedical Engineering
JF - Biocybernetics and Biomedical Engineering
IS - 3
ER -
