Assessment of ischemic stroke rat using near infrared spectroscopy

F. M. Yang, C. W. Wu, C. Y. Lu, J. J. Jason Chen

研究成果: Conference contribution

摘要

Although varied approaches have been developed for quantifying the severity of cerebral dysfunction under ischemic stroke, the neurological scoring and behavior assessment cannot provide noninvasively time-course assessment. The aims of this study are to design non-invasive electrophysiological and optical method to assess the brain recovery of ischemic stroke. The recording system for somatosensory evoked potentials (SSEPs) using surface electrode and neurovascular response using near infrared spectroscopy (NIRS) was developed. A cranial probe was designed to arrange sensing electrodes and optical fibers for concurrent electrical and optical signal acquisition. The pin electrodes consist of spring electrode probe which can provide the well-contact between brain skull and electrode. The Continuous-Wave (CW) NIRS was employed to monitor in-vivo hemodynamic response using avalanche photodiodes (APD). Our results of SSEPs show decayed P1-N1 amplitude and frequency shifted in time frquency analysis after cerebral ischemia. In the future study, our NIRS system will be expanded to employ three wavelengths, which allows the assessment of cytochrome C oxidase. The integration of neurovascular assessment and low level laser therapy (LLLT) system should provide useful tool for time-course monitoring of various novel treatments to the animal of ischemic stroke.

原文English
主出版物標題5th Kuala Lumpur International Conference on Biomedical Engineering 2011, BIOMED 2011
頁面600-603
頁數4
DOIs
出版狀態Published - 2011
事件5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, Held in Conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering, APCMBE 2011 - Kuala Lumpur, Malaysia
持續時間: 2011 六月 202011 六月 23

出版系列

名字IFMBE Proceedings
35 IFMBE
ISSN(列印)1680-0737

Other

Other5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, Held in Conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering, APCMBE 2011
國家/地區Malaysia
城市Kuala Lumpur
期間11-06-2011-06-23

All Science Journal Classification (ASJC) codes

  • 生物工程
  • 生物醫學工程

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