TY - JOUR
T1 - Association between cholesterol plasma levels and craving among heroin users
AU - Lin, Shih Hsien
AU - Yang, Yen Kuang
AU - Lee, Sheng Yu
AU - Hsieh, Pei Chun
AU - Chen, Po See
AU - Lu, Ru Band
AU - Chen, Kao Chin
PY - 2012/12
Y1 - 2012/12
N2 - Objective: Lipids may play some roles in the central nervous system functions that are associated with drug addiction. To date, cholesterol is known to influence relapse of cocaine use. However, the relationship between cholesterol and heroin craving is unclear. This study examined the concurrent association between cholesterol and craving. Method: The serum lipid levels of 70 heroin users who were undergoing or had undergone a methadone maintenance therapy were measured. Their craving and demographic data were assessed. Results: Total cholesterol and low-density lipoprotein cholesterol are negatively associated with craving before (r = -0.33, P < 0.01, and r = -0.36, P < 0.01, respectively) and after controlling for the effects of potential confounders (β = -0.38, P < 0.01, and β = -0.42, P < 0.01, respectively). Conclusions: Cholesterol could be associated with the cognitive aspect of craving and may be a potential marker to predict risk of drug relapse.
AB - Objective: Lipids may play some roles in the central nervous system functions that are associated with drug addiction. To date, cholesterol is known to influence relapse of cocaine use. However, the relationship between cholesterol and heroin craving is unclear. This study examined the concurrent association between cholesterol and craving. Method: The serum lipid levels of 70 heroin users who were undergoing or had undergone a methadone maintenance therapy were measured. Their craving and demographic data were assessed. Results: Total cholesterol and low-density lipoprotein cholesterol are negatively associated with craving before (r = -0.33, P < 0.01, and r = -0.36, P < 0.01, respectively) and after controlling for the effects of potential confounders (β = -0.38, P < 0.01, and β = -0.42, P < 0.01, respectively). Conclusions: Cholesterol could be associated with the cognitive aspect of craving and may be a potential marker to predict risk of drug relapse.
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U2 - 10.1097/ADM.0b013e318262a9a1
DO - 10.1097/ADM.0b013e318262a9a1
M3 - Article
C2 - 22895461
AN - SCOPUS:84871224599
SN - 1932-0620
VL - 6
SP - 287
EP - 291
JO - Journal of Addiction Medicine
JF - Journal of Addiction Medicine
IS - 4
ER -