Association between cholesterol plasma levels and craving among heroin users

Shih Hsien Lin, Yen-Kuang Yang, Sheng Yu Lee, Pei-Chun Hsieh, Po-See Chen, Ru-Band Lu, Kao-Ching Chen

研究成果: Article

14 引文 斯高帕斯(Scopus)

摘要

Objective: Lipids may play some roles in the central nervous system functions that are associated with drug addiction. To date, cholesterol is known to influence relapse of cocaine use. However, the relationship between cholesterol and heroin craving is unclear. This study examined the concurrent association between cholesterol and craving. Method: The serum lipid levels of 70 heroin users who were undergoing or had undergone a methadone maintenance therapy were measured. Their craving and demographic data were assessed. Results: Total cholesterol and low-density lipoprotein cholesterol are negatively associated with craving before (r = -0.33, P < 0.01, and r = -0.36, P < 0.01, respectively) and after controlling for the effects of potential confounders (β = -0.38, P < 0.01, and β = -0.42, P < 0.01, respectively). Conclusions: Cholesterol could be associated with the cognitive aspect of craving and may be a potential marker to predict risk of drug relapse.

原文English
頁(從 - 到)287-291
頁數5
期刊Journal of Addiction Medicine
6
發行號4
DOIs
出版狀態Published - 2012 十二月 1

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Pharmacology (medical)

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