摘要
Most common psychiatric diseases have been found to be associated with disturbance of both the hypothalamic-pituitary-adrenal (HPA) axis and the brain serotonergic system. The aim of this study was to explore the neuroendocrine relationships between the dexamethasone suppression test (DST) and serotonin transporter (SERT) availability in healthy volunteers. Sixty-six participants (30 males and 36 females) were recruited from the community. The DST suppression rate (D%) is the reduction in cortisol level from Day 1 (D1) to Day 2 (D2) in proportion to the Day 1 cortisol level (D%=(D1-D2)/D1×100%). SPECT with [123I] ADAM was used to measure SERT availability. A significant correlation between D% and SERT availability was noted in all subjects (Spearman's ρ=0.26, p=0.03) and in the male subjects (Spearman's ρ=0.41, p=0.02). SERT availability may be sensitive to changes in DST, especially in males.
原文 | English |
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頁(從 - 到) | 641-646 |
頁數 | 6 |
期刊 | European Neuropsychopharmacology |
卷 | 22 |
發行號 | 9 |
DOIs | |
出版狀態 | Published - 2012 9月 |
All Science Journal Classification (ASJC) codes
- 藥理
- 神經內科
- 神經病學(臨床)
- 精神病學和心理健康
- 生物精神病學
- 藥學(醫學)