Association between the dexamethasone suppression test and serotonin transporter availability in healthy volunteers - A SPECT with [123I] ADAM study

Hsiang Yi Tsai, I. Hui Lee, Tzung Lieh Yeh, Wei Jen Yao, Kao Chin Chen, Po See Chen, Nan Tsing Chiu, Ru Band Lu, Yen Kuang Yang

研究成果: Article

10 引文 斯高帕斯(Scopus)

摘要

Most common psychiatric diseases have been found to be associated with disturbance of both the hypothalamic-pituitary-adrenal (HPA) axis and the brain serotonergic system. The aim of this study was to explore the neuroendocrine relationships between the dexamethasone suppression test (DST) and serotonin transporter (SERT) availability in healthy volunteers. Sixty-six participants (30 males and 36 females) were recruited from the community. The DST suppression rate (D%) is the reduction in cortisol level from Day 1 (D1) to Day 2 (D2) in proportion to the Day 1 cortisol level (D%=(D1-D2)/D1×100%). SPECT with [123I] ADAM was used to measure SERT availability. A significant correlation between D% and SERT availability was noted in all subjects (Spearman's ρ=0.26, p=0.03) and in the male subjects (Spearman's ρ=0.41, p=0.02). SERT availability may be sensitive to changes in DST, especially in males.

原文English
頁(從 - 到)641-646
頁數6
期刊European Neuropsychopharmacology
22
發行號9
DOIs
出版狀態Published - 2012 九月 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

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