Association between the diagnosis-to-treatment interval and overall survival in Taiwanese patients with oral cavity squamous cell carcinoma

Chun Ta Liao, Hsin Ni Chen, Yu Wen Wen, Shu Ru Lee, Shu Hang Ng, Tsang Wu Liu, Sen Tien Tsai, Ming Hsui Tsai, Jin Ching Lin, Pei Jen Lou, Cheng Ping Wang, Pen Yuan Chu, Yi Shing Leu, Kuo Yang Tsai, Shyuang Der Terng, Tsung Ming Chen, Cheng Hsu Wang, Chih Yen Chien, Wen Cheng Chen, Li Yu LeeChien Yu Lin, Hung Ming Wang, Chih Hung Lin, Tuan Jen Fang, Shiang Fu Huang, Chung Jan Kang, Kai Ping Chang, Lan Yan Yang, Tzu Chen Yen

研究成果: Article同行評審

17 引文 斯高帕斯(Scopus)

摘要

Background To investigate the association between the diagnosis-to-treatment interval (DTI) and overall survival (OS) in patients with oral cavity squamous cell carcinoma (OSCC). Methods A total of 18,677 patients with first primary OSCC identified in the Taiwanese Cancer Registry Database between 2004 and 2010 were examined. The effect of DTI on 5-year OS rates was investigated with multivariate Cox regression analysis. After the identification of the optimal cutoff for DTI based on the 5-year OS rates, DTI was classified in the following 20-day groups: ≤20 days (57% of the study patients), 21–45 days (34%), 46–90 days (6%) and ≥91 days (3%). In additional exploratory analyses, DTI was reclassified in the following 30-day interval groups: ≤30 days (81% of the study patients), 31–60 days (14%), 61–90 days (2%) and ≥91 days (3%). Results Multivariate analyses identified DTI (≤20 days versus other subgroups), sex (female versus male), age (<65 versus ≥65 years), clinical stage (p-stage I versus p-stage II, III, IV) and treatment modality (initial surgery versus initial non-surgery) as independent prognostic factors for 5-year OS. Compared with a DTI ≤20 days, the DTI categories ≥91 days (hazard ratio [HR]: 1.28, P < 0.001), 46–90 days (HR: 1.25, P < 0.001) and 21–45 days (HR: 1.07, P = 0.007) were independently associated with a higher risk of 5-year mortality. Similar results were obtained for DTI ≤30 days groups. Conclusions DTI is independently associated with 5-year OS in OSCC patients. A DTI longer than 30 days or even 20 days may potentially decrease survival.

原文English
頁(從 - 到)226-234
頁數9
期刊European Journal of Cancer
72
DOIs
出版狀態Published - 2017 二月 1

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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