Association of adiponectin with procollagen type I carboxyterminal propeptide in non-diabetic essential hypertension

研究成果: Article

11 引文 (Scopus)

摘要

Objective. The serum concentration of procollagen type I carboxyterminal propeptide (PICP) is a good marker for collagen deposition in hypertension. Increased collagen deposition was associated with myocardial fibrosis and increased arterial stiffness. A decreased adiponectin level is associated with increased atherosclerosis. The role of adiponectin and its relation to PICP in essential hypertension have rarely been studied before. Methods. We recruited 188 non-diabetic uncomplicated hypertensive patients (mean age: 41 ± 7 years; 128 men). No patient had vascular complications or renal or liver diseases. Overnight fasting blood samples were collected to assess patient lipid profiles, blood sugar, insulin, high-sensitivity C-reactive protein (hsCRP), PICP and adiponectin. Carotid to radial pulse wave velocity (PWV) measured using tonometry was used as an index of arterial stiffness. Results. Adiponectin (r = -0.216, p = 0.003) and male gender (p < 0.001) were independent determinants of PICP. Diastolic blood pressure (r = 0.422, p < 0.001) and current smoking (p = 0.005) were independent determinants of PWV. PWV was significantly correlated with PICP (r = 0.156, p = 0.034). Adiponectin was significantly correlated with triglyceride (r = -0.276, p < 0.001), high-density lipoprotein (r = 0.262, p < 0.001), the homeostasis model assessment (HOMA) index (r = -0.220, p = 0.002), hsCRP (r = -0.207, p = 0.004) and the body mass index (BMI) (r = -0.202, p = 0.005). After compensation with possible confounding factors, adiponectin was still significantly correlated with PICP (beta = -0.196, p = 0.006). Conclusion. Serum adiponectin may be amarker for metabolic syndrome in essential hypertension. Adiponectin was significantly negatively correlated with PICP. Metabolic syndrome probably plays an important role in increased collagen synthesis and arterial stiffness through the effects of decreased adiponectin in non-diabetic essential hypertension.

原文English
頁(從 - 到)233-238
頁數6
期刊Blood Pressure
17
發行號4
DOIs
出版狀態Published - 2008 十二月 1

指紋

Adiponectin
Collagen Type I
Pulse Wave Analysis
Vascular Stiffness
Collagen
C-Reactive Protein
Blood Pressure
Essential Hypertension
Manometry
HDL Lipoproteins
Serum
Blood Vessels
Insulin Resistance
Blood Glucose
Liver Diseases
Fasting
Atherosclerosis
Triglycerides
Body Mass Index
Homeostasis

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

引用此文

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title = "Association of adiponectin with procollagen type I carboxyterminal propeptide in non-diabetic essential hypertension",
abstract = "Objective. The serum concentration of procollagen type I carboxyterminal propeptide (PICP) is a good marker for collagen deposition in hypertension. Increased collagen deposition was associated with myocardial fibrosis and increased arterial stiffness. A decreased adiponectin level is associated with increased atherosclerosis. The role of adiponectin and its relation to PICP in essential hypertension have rarely been studied before. Methods. We recruited 188 non-diabetic uncomplicated hypertensive patients (mean age: 41 ± 7 years; 128 men). No patient had vascular complications or renal or liver diseases. Overnight fasting blood samples were collected to assess patient lipid profiles, blood sugar, insulin, high-sensitivity C-reactive protein (hsCRP), PICP and adiponectin. Carotid to radial pulse wave velocity (PWV) measured using tonometry was used as an index of arterial stiffness. Results. Adiponectin (r = -0.216, p = 0.003) and male gender (p < 0.001) were independent determinants of PICP. Diastolic blood pressure (r = 0.422, p < 0.001) and current smoking (p = 0.005) were independent determinants of PWV. PWV was significantly correlated with PICP (r = 0.156, p = 0.034). Adiponectin was significantly correlated with triglyceride (r = -0.276, p < 0.001), high-density lipoprotein (r = 0.262, p < 0.001), the homeostasis model assessment (HOMA) index (r = -0.220, p = 0.002), hsCRP (r = -0.207, p = 0.004) and the body mass index (BMI) (r = -0.202, p = 0.005). After compensation with possible confounding factors, adiponectin was still significantly correlated with PICP (beta = -0.196, p = 0.006). Conclusion. Serum adiponectin may be amarker for metabolic syndrome in essential hypertension. Adiponectin was significantly negatively correlated with PICP. Metabolic syndrome probably plays an important role in increased collagen synthesis and arterial stiffness through the effects of decreased adiponectin in non-diabetic essential hypertension.",
author = "Tsai, {Wei Chuan} and Lin, {Chih Chan} and Chen, {Ju Yi} and Huang, {Yao Yi} and Lee, {Cheng Han} and Li, {Wei Ting} and Weng, {Chiung Mei} and Chen, {Jyh Hong}",
year = "2008",
month = "12",
day = "1",
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language = "English",
volume = "17",
pages = "233--238",
journal = "Blood Pressure",
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TY - JOUR

T1 - Association of adiponectin with procollagen type I carboxyterminal propeptide in non-diabetic essential hypertension

AU - Tsai, Wei Chuan

AU - Lin, Chih Chan

AU - Chen, Ju Yi

AU - Huang, Yao Yi

AU - Lee, Cheng Han

AU - Li, Wei Ting

AU - Weng, Chiung Mei

AU - Chen, Jyh Hong

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Objective. The serum concentration of procollagen type I carboxyterminal propeptide (PICP) is a good marker for collagen deposition in hypertension. Increased collagen deposition was associated with myocardial fibrosis and increased arterial stiffness. A decreased adiponectin level is associated with increased atherosclerosis. The role of adiponectin and its relation to PICP in essential hypertension have rarely been studied before. Methods. We recruited 188 non-diabetic uncomplicated hypertensive patients (mean age: 41 ± 7 years; 128 men). No patient had vascular complications or renal or liver diseases. Overnight fasting blood samples were collected to assess patient lipid profiles, blood sugar, insulin, high-sensitivity C-reactive protein (hsCRP), PICP and adiponectin. Carotid to radial pulse wave velocity (PWV) measured using tonometry was used as an index of arterial stiffness. Results. Adiponectin (r = -0.216, p = 0.003) and male gender (p < 0.001) were independent determinants of PICP. Diastolic blood pressure (r = 0.422, p < 0.001) and current smoking (p = 0.005) were independent determinants of PWV. PWV was significantly correlated with PICP (r = 0.156, p = 0.034). Adiponectin was significantly correlated with triglyceride (r = -0.276, p < 0.001), high-density lipoprotein (r = 0.262, p < 0.001), the homeostasis model assessment (HOMA) index (r = -0.220, p = 0.002), hsCRP (r = -0.207, p = 0.004) and the body mass index (BMI) (r = -0.202, p = 0.005). After compensation with possible confounding factors, adiponectin was still significantly correlated with PICP (beta = -0.196, p = 0.006). Conclusion. Serum adiponectin may be amarker for metabolic syndrome in essential hypertension. Adiponectin was significantly negatively correlated with PICP. Metabolic syndrome probably plays an important role in increased collagen synthesis and arterial stiffness through the effects of decreased adiponectin in non-diabetic essential hypertension.

AB - Objective. The serum concentration of procollagen type I carboxyterminal propeptide (PICP) is a good marker for collagen deposition in hypertension. Increased collagen deposition was associated with myocardial fibrosis and increased arterial stiffness. A decreased adiponectin level is associated with increased atherosclerosis. The role of adiponectin and its relation to PICP in essential hypertension have rarely been studied before. Methods. We recruited 188 non-diabetic uncomplicated hypertensive patients (mean age: 41 ± 7 years; 128 men). No patient had vascular complications or renal or liver diseases. Overnight fasting blood samples were collected to assess patient lipid profiles, blood sugar, insulin, high-sensitivity C-reactive protein (hsCRP), PICP and adiponectin. Carotid to radial pulse wave velocity (PWV) measured using tonometry was used as an index of arterial stiffness. Results. Adiponectin (r = -0.216, p = 0.003) and male gender (p < 0.001) were independent determinants of PICP. Diastolic blood pressure (r = 0.422, p < 0.001) and current smoking (p = 0.005) were independent determinants of PWV. PWV was significantly correlated with PICP (r = 0.156, p = 0.034). Adiponectin was significantly correlated with triglyceride (r = -0.276, p < 0.001), high-density lipoprotein (r = 0.262, p < 0.001), the homeostasis model assessment (HOMA) index (r = -0.220, p = 0.002), hsCRP (r = -0.207, p = 0.004) and the body mass index (BMI) (r = -0.202, p = 0.005). After compensation with possible confounding factors, adiponectin was still significantly correlated with PICP (beta = -0.196, p = 0.006). Conclusion. Serum adiponectin may be amarker for metabolic syndrome in essential hypertension. Adiponectin was significantly negatively correlated with PICP. Metabolic syndrome probably plays an important role in increased collagen synthesis and arterial stiffness through the effects of decreased adiponectin in non-diabetic essential hypertension.

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