Association of sex hormone receptor gene polymorphisms with recurrent pregnancy loss: A systematic review and meta-analysis

研究成果: Article

24 引文 (Scopus)

摘要

Objective: To investigate the genetic association between estrogen and progesterone receptor polymorphisms (ER, PR) and skewed X chromosome inactivation (XCI) and idiopathic recurrent pregnancy loss (RPL). Design: A systematic review and meta-analysis using electronic database (MEDLINE and EMBASE) up to April 2011. Setting: 24 eligible studies from 14 countries. Patient(s): 2,750 RPL patients and 3,123 controls were included. Intervention(s): Meta-analyses by means of random-effects models. Main Outcome Measurement(s): Common polymorphisms of ER and PR and skewed XCI. Result(s): Of 221 potentially relevant studies, 24 case-control studies were included: 6 reports of PR polymorphisms (PROGINS), 6 reports of ER-α (3 each of rs2234693 [PvuII], rs9340799 [XbaI], and B domain) and 12 reports of skewed XCI. The integrated result showed that women with skewed XCI (>90%) had a higher risk for RPL (the summary OR [95% CI]: 2.43 [1.34-4.43]), and the subgroup analysis of those studies that included more than three consecutive miscarriages (5 studies), also showed a significant association with RPL (2.52 [1.16-5.44]). Among studies of PR (PROGINS) and ER (PuvII, XbaI, B domain) polymorphisms in RPL, the summary ORs were 1.46 (0.56-3.79), 0.90 (0.47-1.75), 0.83 (0.53-1.29), and 1.07 (0.43-2.63), respectively. Conclusion(s): Meta-analyses of the available data showed a significant association between skewed XCI and idiopathic RPL. More data on the associations between ER and PR polymorphisms and RPL would be helpful to elucidate their roles in RPL.

原文English
期刊Fertility and Sterility
96
發行號6
DOIs
出版狀態Published - 2011 一月 1

指紋

Gonadal Steroid Hormones
X Chromosome Inactivation
Meta-Analysis
Pregnancy
Genes
High-Risk Pregnancy
Spontaneous Abortion
Progesterone Receptors
MEDLINE
Estrogen Receptors
Case-Control Studies
Databases

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynaecology

引用此文

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title = "Association of sex hormone receptor gene polymorphisms with recurrent pregnancy loss: A systematic review and meta-analysis",
abstract = "Objective: To investigate the genetic association between estrogen and progesterone receptor polymorphisms (ER, PR) and skewed X chromosome inactivation (XCI) and idiopathic recurrent pregnancy loss (RPL). Design: A systematic review and meta-analysis using electronic database (MEDLINE and EMBASE) up to April 2011. Setting: 24 eligible studies from 14 countries. Patient(s): 2,750 RPL patients and 3,123 controls were included. Intervention(s): Meta-analyses by means of random-effects models. Main Outcome Measurement(s): Common polymorphisms of ER and PR and skewed XCI. Result(s): Of 221 potentially relevant studies, 24 case-control studies were included: 6 reports of PR polymorphisms (PROGINS), 6 reports of ER-α (3 each of rs2234693 [PvuII], rs9340799 [XbaI], and B domain) and 12 reports of skewed XCI. The integrated result showed that women with skewed XCI (>90{\%}) had a higher risk for RPL (the summary OR [95{\%} CI]: 2.43 [1.34-4.43]), and the subgroup analysis of those studies that included more than three consecutive miscarriages (5 studies), also showed a significant association with RPL (2.52 [1.16-5.44]). Among studies of PR (PROGINS) and ER (PuvII, XbaI, B domain) polymorphisms in RPL, the summary ORs were 1.46 (0.56-3.79), 0.90 (0.47-1.75), 0.83 (0.53-1.29), and 1.07 (0.43-2.63), respectively. Conclusion(s): Meta-analyses of the available data showed a significant association between skewed XCI and idiopathic RPL. More data on the associations between ER and PR polymorphisms and RPL would be helpful to elucidate their roles in RPL.",
author = "Mei-Tsz Su and Sheng-Hsiang Lin and Yi-Chi Chen",
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AB - Objective: To investigate the genetic association between estrogen and progesterone receptor polymorphisms (ER, PR) and skewed X chromosome inactivation (XCI) and idiopathic recurrent pregnancy loss (RPL). Design: A systematic review and meta-analysis using electronic database (MEDLINE and EMBASE) up to April 2011. Setting: 24 eligible studies from 14 countries. Patient(s): 2,750 RPL patients and 3,123 controls were included. Intervention(s): Meta-analyses by means of random-effects models. Main Outcome Measurement(s): Common polymorphisms of ER and PR and skewed XCI. Result(s): Of 221 potentially relevant studies, 24 case-control studies were included: 6 reports of PR polymorphisms (PROGINS), 6 reports of ER-α (3 each of rs2234693 [PvuII], rs9340799 [XbaI], and B domain) and 12 reports of skewed XCI. The integrated result showed that women with skewed XCI (>90%) had a higher risk for RPL (the summary OR [95% CI]: 2.43 [1.34-4.43]), and the subgroup analysis of those studies that included more than three consecutive miscarriages (5 studies), also showed a significant association with RPL (2.52 [1.16-5.44]). Among studies of PR (PROGINS) and ER (PuvII, XbaI, B domain) polymorphisms in RPL, the summary ORs were 1.46 (0.56-3.79), 0.90 (0.47-1.75), 0.83 (0.53-1.29), and 1.07 (0.43-2.63), respectively. Conclusion(s): Meta-analyses of the available data showed a significant association between skewed XCI and idiopathic RPL. More data on the associations between ER and PR polymorphisms and RPL would be helpful to elucidate their roles in RPL.

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