Association of subtle left ventricular systolic dysfunction with elevated cardiac troponin T in asymptomatic hemodialysis patients with preserved left ventricular ejection fraction

Yen Wen Liu, Chi Ting Su, Chih Chen Chou, Saprina P.H. Wang, Chun Shin Yang, Yao Yi Huang, Liang Miin Tsai, Jyh Hong Chen, Wei Chuan Tsai

研究成果: Article

4 引文 斯高帕斯(Scopus)

摘要

Background: Increased cardiac troponin T (cTnT) concentrations are associated with a poor prognosis in end-stage renal disease (ESRD) patients. However, the impact of increased cTnT levels on left ventricular (LV) function is not well understood. Therefore, our study focused on LV function in asymptomatic hemodialysis patients with preserved left ventricular ejection fraction (LVEF) and elevated cTnT levels. Methods: Asymptomatic ESRD patients undergoing maintenance hemodialysis, with LVEF ≥ 50%, underwent echocardiographic examination and further testing to determine serum cTnT, high-sensitivity C-reactive protein (hsCRP) and albumin levels. Subjects were then stratified into one of two groups based on the cTnT level, with a cutoff value of 0.04 ng/mL. Results: There were no significant differences in gender, age, LVEF, systolic myocardial velocity, and the prevalence of comorbidities (except diabetes mellitus) between these two groups. Patients in the high cTnT group (≥ 0.04 ng/mL) presented with higher hsCRP levels than patients in the low cTnT group (1.50 ± 0.35 mg/dL vs. 0.59 ± 0.62 mg/dL, p = 0.02). Additionally, reduced global LVpeak systolic longitudinal strain (GLS) developed in the high cTnT group compared with the low group (-17.1 ± 3.7% vs. -19.4 ± 3.5%, p = 0.004). The deteriorated GLS was an independent factor correlated with higher cTnT levels in asymptomatic hemodialysis patients with preserved LVEF (p = 0.013, 95% CI = 0.71-0.96). Conclusion: Patients in the high cTnT group presented with higher levels of hsCRP andmore reduced GLS than those in the low cTnT group, and reduced GLS was the independent factor of elevated cTnT level. Consequently, we concluded that those asymptomatic hemodialysis patients with elevated cTnT concentrations had LV systolic dysfunction.

原文English
頁(從 - 到)95-102
頁數8
期刊Acta Cardiologica Sinica
28
發行號2
出版狀態Published - 2012 六月 1

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

指紋 深入研究「Association of subtle left ventricular systolic dysfunction with elevated cardiac troponin T in asymptomatic hemodialysis patients with preserved left ventricular ejection fraction」主題。共同形成了獨特的指紋。

  • 引用此