Association study of the norepinephrine transporter gene polymorphisms and bipolar disorder in Han Chinese population

Chuan Chia Chang, Ru Band Lu, Kuo Hsing Ma, Hsin An Chang, Chih Lun Chen, Cheng Chang Huang, Wei Wen Lin, San Yuan Huang

研究成果: Article同行評審

7 引文 斯高帕斯(Scopus)

摘要

Many studies have indicated that the norepinephrine transporter (NET) may play an important role in the mechanisms underlying affective disorders. Thus, the genes of the NET (SLC6A2) are good candidates for research on bipolar disorder (BPD). This study examined whether the NET gene is a susceptibility factor for the BPD in Han Chinese. A promoter -182 T/C polymorphism (rs 2242446) and the exonic polymorphism 1287 G/A (rs 5569) of the NET gene were analysed using a polymerase chain reaction (PCR)-based method in 261 BPD patients and 245 unrelated, age- and gender-matched controls. Furthermore, to reduce the clinical heterogeneity, we also carried out analysis in clinical subgroups of bipolar patients defined according to type I and type II BPD, presence or absence of family history of major affective disorders and the age at onset of BPD. No significant difference was found between either bipolar patients or its more homogeneous subgroups and healthy controls in the genotype and allele frequencies for the investigated NET polymorphisms. Our results suggest that the investigated polymorphisms of NET are not major risk factors responsible for predisposition to BPD or its clinical subtypes in Han Chinese. However, replication studies with larger different ethnic samples are needed.

原文English
頁(從 - 到)188-195
頁數8
期刊World Journal of Biological Psychiatry
8
發行號3
DOIs
出版狀態Published - 2007

All Science Journal Classification (ASJC) codes

  • 精神病學和心理健康
  • 生物精神病學

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