TY - JOUR
T1 - Associations of parental mental disorders and age with childhood mental disorders
T2 - a population-based cohort study with four million offspring
AU - Liang, Chih Sung
AU - Bai, Ya Mei
AU - Hsu, Ju Wei
AU - Huang, Kai Lin
AU - Ko, Nai Ying
AU - Yeh, Ta Chuan
AU - Chu, Hsuan Te
AU - Tsai, Shih Jen
AU - Chen, Tzeng Ji
AU - Chen, Mu Hong
N1 - Funding Information:
The study was supported by grant from Taipei Veterans General Hospital (V106B-020, V107B-010, V107C-181, V107C-052) and Ministry of Science and Technology, Taiwan (107–2314-B-075–063-MY3). The funding source had no role in any process of study.
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
PY - 2023/5
Y1 - 2023/5
N2 - This Taiwan study examined the associations of parental age and mental disorders with the offspring risks of attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), major depressive disorder (MDD), and bipolar disorder (BD). Children born between January 1991 and December 2004 in Taiwan were enrolled as the birth cohort (n = 4,138,151) and followed up until December 2011. A logistic regression analysis was performed to identify the odds ratio (OR). The advanced age effects were significant in ADHD (range of OR: 1.04 to 1.49) and ASD (range of OR: 1.35 to 2.27). Teenage mothers, teenage fathers, and fathers ≥ 50 years had higher offspring risks of MDD (range of OR: 1.24 to 1.46); and teenage mothers and fathers ≥ 50 years had increased offspring risks of BD (range of OR: 1.23 to 1.87). Both paternal and maternal mental disorders were associated with higher risks of within-disorder transmission for ADHD, ASD, MDD, and BD (range of OR: 2.64 to 30.41). Besides, parents with one of these four mental disorders (ADHD, ASD, MDD, and BD) might have higher risk of cross-disorder transmission to at least one of the other three mental disorders in the offspring (range of OR: 1.35 to 7.15). Parental age and mental disorders had complex and nuanced patterns in association with offspring mental disorders.
AB - This Taiwan study examined the associations of parental age and mental disorders with the offspring risks of attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), major depressive disorder (MDD), and bipolar disorder (BD). Children born between January 1991 and December 2004 in Taiwan were enrolled as the birth cohort (n = 4,138,151) and followed up until December 2011. A logistic regression analysis was performed to identify the odds ratio (OR). The advanced age effects were significant in ADHD (range of OR: 1.04 to 1.49) and ASD (range of OR: 1.35 to 2.27). Teenage mothers, teenage fathers, and fathers ≥ 50 years had higher offspring risks of MDD (range of OR: 1.24 to 1.46); and teenage mothers and fathers ≥ 50 years had increased offspring risks of BD (range of OR: 1.23 to 1.87). Both paternal and maternal mental disorders were associated with higher risks of within-disorder transmission for ADHD, ASD, MDD, and BD (range of OR: 2.64 to 30.41). Besides, parents with one of these four mental disorders (ADHD, ASD, MDD, and BD) might have higher risk of cross-disorder transmission to at least one of the other three mental disorders in the offspring (range of OR: 1.35 to 7.15). Parental age and mental disorders had complex and nuanced patterns in association with offspring mental disorders.
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U2 - 10.1007/s00787-021-01914-3
DO - 10.1007/s00787-021-01914-3
M3 - Article
C2 - 34802066
AN - SCOPUS:85119486481
SN - 1018-8827
VL - 32
SP - 825
EP - 833
JO - European Child and Adolescent Psychiatry
JF - European Child and Adolescent Psychiatry
IS - 5
ER -
