Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer

Ya Shih Tseng, Ching Cherng Tzeng, Chi Ying F. Huang, Ping Hong Chen, Allen Wen Hsiang Chiu, Pei Yin Hsu, Guan Cheng Huang, Yu Chun Wang, Hsiao Sheng Liu

研究成果: Article

12 引文 斯高帕斯(Scopus)

摘要

Our data revealed that 59.4% of the bladder cancer specimens showed Aurora-A overexpression, of which 31.8% also had Ha-. ras codon-12 mutation; 45.5% were from blackfoot-disease endemic areas in which arsenic exposure is a major environment factor associated with various cancer formation. We further demonstrated that arsenic treatment of the immortalized bladder cell line, E7, increased Aurora-A expression. All together, co-existence of Aurora-A overexpression and Ha-. ras mutation suggests a possible additively effect on the tumorigenesis of bladder cancer. In addition, Aurora-A overexpression and up-regulated by arsenic exposure opens a new direction for exploring the occurrence of bladder cancer occurrence in Taiwan.

原文English
頁(從 - 到)93-101
頁數9
期刊Cancer Letters
241
發行號1
DOIs
出版狀態Published - 2006 九月 8

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Tseng, Y. S., Tzeng, C. C., Huang, C. Y. F., Chen, P. H., Chiu, A. W. H., Hsu, P. Y., Huang, G. C., Wang, Y. C., & Liu, H. S. (2006). Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer. Cancer Letters, 241(1), 93-101. https://doi.org/10.1016/j.canlet.2005.10.014