Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold

Mohane Selvaraj Coumar, Jian Sung Wu, Jiun Shyang Leou, Uan Kang Tan, Chung Yu Chang, Teng Yuan Chang, Wen Hsing Lin, John T.A. Hsu, Yu Sheng Chao, Su Ying Wu, Hsing Pang Hsieh

研究成果: Article同行評審

28 引文 斯高帕斯(Scopus)

摘要

Tricyclic 6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione was identified as a novel scaffold for Aurora kinase A inhibition through virtual screening. SAR exploration coupled with molecular modeling of 8a reveals the minimum pharmacophore requirements for Aurora kinase A inhibition.

原文English
頁(從 - 到)1623-1627
頁數5
期刊Bioorganic and Medicinal Chemistry Letters
18
發行號5
DOIs
出版狀態Published - 2008 三月 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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