Autoantibody profiling of monoamine oxidase A knockout mice, an autism spectrum disorder model

Guan Da Syu, F. X.Reymond Sutandy, Kevin Chen, Yawei Cheng, Chien Sheng Chen, Jean C. Shih

研究成果: Article同行評審


Monoamine oxidase A (MAO A) is the critical enzyme to degrade serotonin in the brain and the knockout mouse exhibits hyperserotonemia and abnormalities that are observed in autism spectrum disorder (ASD). Thus, the MAO A knockout mouse is a valuable model for studying neurological and behavioral impairments in ASD. Based on the immune dysfunction hypothesis, dysregulated humoral immunity may cause neurological impairments. To address this hypothesis, we use high-density proteome microarray to profile the serum antibodies in both wild-type and MAO A knockout mice. The distingue autoantibody signatures were observed in the MAO A knockout and wild-type controls and showed 165 up-regulated and 232 down-regulated autoantibodies. The up-regulated autoantibodies were prone to target brain tissues while down-regulated ones were enriched in sex organs. The identified autoantibodies help bridge the gap between ASD mouse models and humoral immunity, not only yielding insights into the pathological mechanisms but also providing potential biomarkers for translational research in ASD.

頁(從 - 到)193-200
期刊Brain, Behavior, and Immunity
出版狀態Published - 2023 1月

All Science Journal Classification (ASJC) codes

  • 免疫學
  • 內分泌和自主系統
  • 行為神經科學


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