Automatic Detection of Atherosclerotic Plaque and Calcification from Intravascular Ultrasound Images by Using Deep Convolutional Neural Networks

Yi Chen Li, Thau Yun Shen, Chien Cheng Chen, Wei Ting Chang, Po Yang Lee, Chih Chung Johnson Huang

研究成果: Article同行評審

38 引文 斯高帕斯(Scopus)


Atherosclerosis is the major cause of cardiovascular diseases (CVDs). Intravascular ultrasound (IVUS) is a common imaging modality for diagnosing CVDs. However, an efficient analyzer for IVUS image segmentation is required for assisting cardiologists. In this study, an end-to-end deep-learning convolutional neural network was developed for automatically detecting media-adventitia borders, luminal regions, and calcified plaque in IVUS images. A total of 713 grayscale IVUS images from 18 patients were used as training data for the proposed deep-learning model. The model is constructed using the three modified U-Nets and combined with the concept of cascaded networks to prevent errors in the detection of calcification owing to the interference of pixels outside the plaque regions. Three loss functions (Dice, Tversky, and focal loss) with various characteristics were tested to determine the best setting for the proposed model. The efficacy of the deep-learning model was evaluated by analyzing precision-recall curve. The average precision (AP), Dice score coefficient, precision, sensitivity, and specificity of the predicted and ground truth results were then compared. All training processes were validated using leave-one-subject-out cross-validation. The experimental results showed that the proposed deep-learning model exhibits high performance in segmenting the media-adventitia layers and luminal regions for all loss functions, with all tested metrics being higher than 0.90. For locating calcified tissues, the best result was obtained when the focal loss function was applied to the proposed model, with an AP of 0.73; however, the prediction efficacy was affected by the proportion of calcified tissues within the plaque region when the focal loss function was employed. Compared with commercial software, the proposed method exhibited high accuracy in segmenting IVUS images in some special cases, such as when shadow artifacts or side vessels surrounded the target vessel.

頁(從 - 到)1762-1772
期刊IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
出版狀態Published - 2021 5月

All Science Journal Classification (ASJC) codes

  • 儀器
  • 聲學與超音波
  • 電氣與電子工程


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