Autophagy-inducing effect of pterostilbene: A prospective therapeutic/preventive option for skin diseases

Rong Jane Chen, Yu Hsuan Lee, Ya Ling Yeh, Wun Syuan Wu, Chi Tang Ho, Chia Yi Li, Bour Jr Wang, Ying Jan Wang

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)

摘要

Pterostilbene is a naturally occurring analog of resveratrol with many health benefits. These health benefits are associated with its antioxidant activity, anti-inflammatory effects, and chemopreventive effects attributed to its unique structure. The skin cancer chemopreventive potential of pterostilbene is supported by a variety of mechanistic studies confirming the anti-inflammatory effects in skin cancer models. Molecular biological studies have identified that pterostilbene targets pleotropic signaling pathways, including those involved in mitogenesis, cell cycle regulation, and apoptosis. Recently, pterostilbene has been reported to induce autophagy in cancer and normal cells. Through autophagy induction, the inflammatory-related skin diseases can be attenuated. This finding suggests the potential use of pterostilbene in the treatment and prevention of skin disorders via alleviating inflammatory responses by autophagy induction. This review summarizes the protective and therapeutic benefits of pterostilbene in skin diseases from the viewpoint of its antioxidant, anti-inflammatory, and autophagy-inducing effects. Novel underlying mechanisms regarding these effects are discussed. We proposed that pterostilbene, a promising natural product, can be used as a preventive and therapeutic agent for inflammation-related skin disorders through induction of autophagy.

原文English
頁(從 - 到)125-133
頁數9
期刊Journal of Food and Drug Analysis
25
發行號1
DOIs
出版狀態Published - 2017 一月 1

All Science Journal Classification (ASJC) codes

  • 食品科學
  • 藥理

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