Availability of Striatal Dopamine Transporter in Healthy Individuals With and Without a Family History of ADHD

研究成果: Article

1 引文 (Scopus)

摘要

Objective: ADHD is the most prevalent neurodevelopmental disorder. It is highly heritable and multifactorial, but the definitive causes remain unknown. Abnormal dopamine transporter (DAT) availability has been reported, but the data are inconsistent. The aim of this study was to examine whether DAT availability differs between healthy parents with and without ADHD offspring. Method: Eleven healthy parents with ADHD offspring and 11 age- and sex-matched healthy controls without ADHD offspring were recruited. The availability of DAT was approximated using single-photon emission computed tomography, with [ 99m Tc] TRODAT-1 as the ligand. Results: DAT availability in the basal ganglia, caudate nucleus, and putamen was significantly lower in the parents with ADHD offspring than in the healthy controls without ADHD offspring. Conclusion: The results suggest that ADHD could be heritable via abnormal DAT activities.

原文English
頁(從 - 到)665-670
頁數6
期刊Journal of Attention Disorders
23
發行號7
DOIs
出版狀態Published - 2019 五月 1

指紋

Corpus Striatum
Dopamine Plasma Membrane Transport Proteins
Caudate Nucleus
Putamen
Basal Ganglia
Single-Photon Emission-Computed Tomography
Ligands

All Science Journal Classification (ASJC) codes

  • Developmental and Educational Psychology
  • Clinical Psychology

引用此文

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title = "Availability of Striatal Dopamine Transporter in Healthy Individuals With and Without a Family History of ADHD",
abstract = "Objective: ADHD is the most prevalent neurodevelopmental disorder. It is highly heritable and multifactorial, but the definitive causes remain unknown. Abnormal dopamine transporter (DAT) availability has been reported, but the data are inconsistent. The aim of this study was to examine whether DAT availability differs between healthy parents with and without ADHD offspring. Method: Eleven healthy parents with ADHD offspring and 11 age- and sex-matched healthy controls without ADHD offspring were recruited. The availability of DAT was approximated using single-photon emission computed tomography, with [ 99m Tc] TRODAT-1 as the ligand. Results: DAT availability in the basal ganglia, caudate nucleus, and putamen was significantly lower in the parents with ADHD offspring than in the healthy controls without ADHD offspring. Conclusion: The results suggest that ADHD could be heritable via abnormal DAT activities.",
author = "Ying-Chun Tai and Mei-Hung Chi and Chu, {Ching Lin} and Nan-Tsing Chiu and Wei-Jen Yao and Po-See Chen and Yen-Kuang Yang",
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T1 - Availability of Striatal Dopamine Transporter in Healthy Individuals With and Without a Family History of ADHD

AU - Tai, Ying-Chun

AU - Chi, Mei-Hung

AU - Chu, Ching Lin

AU - Chiu, Nan-Tsing

AU - Yao, Wei-Jen

AU - Chen, Po-See

AU - Yang, Yen-Kuang

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Objective: ADHD is the most prevalent neurodevelopmental disorder. It is highly heritable and multifactorial, but the definitive causes remain unknown. Abnormal dopamine transporter (DAT) availability has been reported, but the data are inconsistent. The aim of this study was to examine whether DAT availability differs between healthy parents with and without ADHD offspring. Method: Eleven healthy parents with ADHD offspring and 11 age- and sex-matched healthy controls without ADHD offspring were recruited. The availability of DAT was approximated using single-photon emission computed tomography, with [ 99m Tc] TRODAT-1 as the ligand. Results: DAT availability in the basal ganglia, caudate nucleus, and putamen was significantly lower in the parents with ADHD offspring than in the healthy controls without ADHD offspring. Conclusion: The results suggest that ADHD could be heritable via abnormal DAT activities.

AB - Objective: ADHD is the most prevalent neurodevelopmental disorder. It is highly heritable and multifactorial, but the definitive causes remain unknown. Abnormal dopamine transporter (DAT) availability has been reported, but the data are inconsistent. The aim of this study was to examine whether DAT availability differs between healthy parents with and without ADHD offspring. Method: Eleven healthy parents with ADHD offspring and 11 age- and sex-matched healthy controls without ADHD offspring were recruited. The availability of DAT was approximated using single-photon emission computed tomography, with [ 99m Tc] TRODAT-1 as the ligand. Results: DAT availability in the basal ganglia, caudate nucleus, and putamen was significantly lower in the parents with ADHD offspring than in the healthy controls without ADHD offspring. Conclusion: The results suggest that ADHD could be heritable via abnormal DAT activities.

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