Aza-ortho-Quinone Methide and Its Conjugated Acid: Reactivity, Stability and Acidity

Tun Hui Wu, Zih Syuan Su, Robert Sung, Kuangsen Sung

研究成果: Article

摘要

Aza-o-quinone methides and their conjugated acids are reactive drug metabolites that might react with nucleophilic sites of DNAs and proteins to cause cancer or immune responses, and their reactivity with water is the key information to judge if these metabolites are harmful in living systems. For the first time, aza-o-quinone methide (1) and its conjugated acid (2) are observed by laser flash photolysis, and their reactivity, stability and acidity in water are determined.

原文English
頁(從 - 到)307-312
頁數6
期刊ChemPhysChem
21
發行號4
DOIs
出版狀態Published - 2020 二月 17

    指紋

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics
  • Physical and Theoretical Chemistry

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