Aza-ortho-Quinone Methide and Its Conjugated Acid: Reactivity, Stability and Acidity

Tun Hui Wu; Zih Syuan Su; Robert Sung; Kuangsen Sung

doi:10.1002/cphc.201901133

Aza-ortho-Quinone Methide and Its Conjugated Acid: Reactivity, Stability and Acidity

Tun Hui Wu, Zih Syuan Su, Robert Sung, Kuangsen Sung

化學系

研究成果: Article › 同行評審

2 引文斯高帕斯（Scopus）

摘要

Aza-o-quinone methides and their conjugated acids are reactive drug metabolites that might react with nucleophilic sites of DNAs and proteins to cause cancer or immune responses, and their reactivity with water is the key information to judge if these metabolites are harmful in living systems. For the first time, aza-o-quinone methide (1) and its conjugated acid (2) are observed by laser flash photolysis, and their reactivity, stability and acidity in water are determined.

原文	English
頁（從 - 到）	307-312
頁數	6
期刊	ChemPhysChem
卷	21
發行號	4
DOIs	https://doi.org/10.1002/cphc.201901133
出版狀態	Published - 2020 2月 17

All Science Journal Classification (ASJC) codes

原子與分子物理與光學
物理與理論化學

UN SDG

此研究成果有助於以下永續發展目標

存取文件

10.1002/cphc.201901133

其它文件與鏈接

引用此

@article{d86777b1f7da46b0bb01d3c9fd26f35b,

title = "Aza-ortho-Quinone Methide and Its Conjugated Acid: Reactivity, Stability and Acidity",

abstract = "Aza-o-quinone methides and their conjugated acids are reactive drug metabolites that might react with nucleophilic sites of DNAs and proteins to cause cancer or immune responses, and their reactivity with water is the key information to judge if these metabolites are harmful in living systems. For the first time, aza-o-quinone methide (1) and its conjugated acid (2) are observed by laser flash photolysis, and their reactivity, stability and acidity in water are determined.",

author = "Wu, {Tun Hui} and Su, {Zih Syuan} and Robert Sung and Kuangsen Sung",

note = "Funding Information: We thank National Science Council of Taiwan for financial support (NSC107‐2113‐M‐006‐011) and National Center for High‐performance Computing for computer facilities and time. Publisher Copyright: {\textcopyright} 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2020",

month = feb,

day = "17",

doi = "10.1002/cphc.201901133",

language = "English",

volume = "21",

pages = "307--312",

journal = "ChemPhysChem",

issn = "1439-4235",

publisher = "Wiley-VCH Verlag",

number = "4",

}

TY - JOUR

T1 - Aza-ortho-Quinone Methide and Its Conjugated Acid

T2 - Reactivity, Stability and Acidity

AU - Wu, Tun Hui

AU - Su, Zih Syuan

AU - Sung, Robert

AU - Sung, Kuangsen

N1 - Funding Information: We thank National Science Council of Taiwan for financial support (NSC107‐2113‐M‐006‐011) and National Center for High‐performance Computing for computer facilities and time. Publisher Copyright: © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2020/2/17

Y1 - 2020/2/17

N2 - Aza-o-quinone methides and their conjugated acids are reactive drug metabolites that might react with nucleophilic sites of DNAs and proteins to cause cancer or immune responses, and their reactivity with water is the key information to judge if these metabolites are harmful in living systems. For the first time, aza-o-quinone methide (1) and its conjugated acid (2) are observed by laser flash photolysis, and their reactivity, stability and acidity in water are determined.

AB - Aza-o-quinone methides and their conjugated acids are reactive drug metabolites that might react with nucleophilic sites of DNAs and proteins to cause cancer or immune responses, and their reactivity with water is the key information to judge if these metabolites are harmful in living systems. For the first time, aza-o-quinone methide (1) and its conjugated acid (2) are observed by laser flash photolysis, and their reactivity, stability and acidity in water are determined.

UR - http://www.scopus.com/inward/record.url?scp=85078682947&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85078682947&partnerID=8YFLogxK

U2 - 10.1002/cphc.201901133

DO - 10.1002/cphc.201901133

M3 - Article

C2 - 31895487

AN - SCOPUS:85078682947

SN - 1439-4235

VL - 21

SP - 307

EP - 312

JO - ChemPhysChem

JF - ChemPhysChem

IS - 4

ER -

Aza-ortho-Quinone Methide and Its Conjugated Acid: Reactivity, Stability and Acidity

摘要

All Science Journal Classification (ASJC) codes

UN SDG

存取文件

其它文件與鏈接

指紋

引用此