TY - JOUR
T1 - Betel nut chewing associated with increased risk of arterial stiffness
AU - Wei, Yu Ting
AU - Chou, Yu Tsung
AU - Yang, Yi Ching
AU - Chou, Chieh Ying
AU - Lu, Feng Hwa
AU - Chang, Chih Jen
AU - Wu, Jin Shang
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Background Betel nut chewing is associated with certain cardiovascular outcomes. Subclinical atherosclerosis may be one link between betel nut chewing and cardiovascular risk. Few studies have examined the association between chewing betel nut and arterial stiffness. The aim of this study was thus to determine the relationship between betel nut chewing and arterial stiffness in a Taiwanese population. Methods We enrolled 7540 eligible subjects in National Cheng Kung University Hospital from October 2006 to August 2009. The exclusion criteria included history of cerebrovascular events, coronary artery disease, and taking lipid-lowering drugs, antihypertensives, and hypoglycemic agents. Increased arterial stiffness was defined as brachial–ankle pulse wave velocity (baPWV) ≥1400 cm/s. According to their habit of betel nut use, the subjects were categorized into non-, ex-, and current chewers. Results The prevalence of increased arterial stiffness was 32.7, 43.3, and 43.2% in non-, ex- and current chewers, respectively (p = 0.011). Multiple logistic regression analysis revealed that ex-chewers (odds ratio [OR] 1.69, 95% confidence interval (CI) = 1.08–2.65) and current chewers (OR 2.29, 95% CI = 1.05–4.99) had elevated risks of increased arterial stiffness after adjustment for co-variables. Conclusions Both ex- and current betel nut chewing were associated with a higher risk of increased arterial stiffness. Stopping betel nut chewing may thus potentially be beneficial to reduce cardiovascular risk, based on the principals of preventive medicine.
AB - Background Betel nut chewing is associated with certain cardiovascular outcomes. Subclinical atherosclerosis may be one link between betel nut chewing and cardiovascular risk. Few studies have examined the association between chewing betel nut and arterial stiffness. The aim of this study was thus to determine the relationship between betel nut chewing and arterial stiffness in a Taiwanese population. Methods We enrolled 7540 eligible subjects in National Cheng Kung University Hospital from October 2006 to August 2009. The exclusion criteria included history of cerebrovascular events, coronary artery disease, and taking lipid-lowering drugs, antihypertensives, and hypoglycemic agents. Increased arterial stiffness was defined as brachial–ankle pulse wave velocity (baPWV) ≥1400 cm/s. According to their habit of betel nut use, the subjects were categorized into non-, ex-, and current chewers. Results The prevalence of increased arterial stiffness was 32.7, 43.3, and 43.2% in non-, ex- and current chewers, respectively (p = 0.011). Multiple logistic regression analysis revealed that ex-chewers (odds ratio [OR] 1.69, 95% confidence interval (CI) = 1.08–2.65) and current chewers (OR 2.29, 95% CI = 1.05–4.99) had elevated risks of increased arterial stiffness after adjustment for co-variables. Conclusions Both ex- and current betel nut chewing were associated with a higher risk of increased arterial stiffness. Stopping betel nut chewing may thus potentially be beneficial to reduce cardiovascular risk, based on the principals of preventive medicine.
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U2 - 10.1016/j.drugalcdep.2017.07.035
DO - 10.1016/j.drugalcdep.2017.07.035
M3 - Article
C2 - 28850901
AN - SCOPUS:85028576854
SN - 0376-8716
VL - 180
SP - 1
EP - 6
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
ER -