Betel nut chewing associated with increased risk of arterial stiffness

研究成果: Article

3 引文 (Scopus)

摘要

Background Betel nut chewing is associated with certain cardiovascular outcomes. Subclinical atherosclerosis may be one link between betel nut chewing and cardiovascular risk. Few studies have examined the association between chewing betel nut and arterial stiffness. The aim of this study was thus to determine the relationship between betel nut chewing and arterial stiffness in a Taiwanese population. Methods We enrolled 7540 eligible subjects in National Cheng Kung University Hospital from October 2006 to August 2009. The exclusion criteria included history of cerebrovascular events, coronary artery disease, and taking lipid-lowering drugs, antihypertensives, and hypoglycemic agents. Increased arterial stiffness was defined as brachial–ankle pulse wave velocity (baPWV) ≥1400 cm/s. According to their habit of betel nut use, the subjects were categorized into non-, ex-, and current chewers. Results The prevalence of increased arterial stiffness was 32.7, 43.3, and 43.2% in non-, ex- and current chewers, respectively (p = 0.011). Multiple logistic regression analysis revealed that ex-chewers (odds ratio [OR] 1.69, 95% confidence interval (CI) = 1.08–2.65) and current chewers (OR 2.29, 95% CI = 1.05–4.99) had elevated risks of increased arterial stiffness after adjustment for co-variables. Conclusions Both ex- and current betel nut chewing were associated with a higher risk of increased arterial stiffness. Stopping betel nut chewing may thus potentially be beneficial to reduce cardiovascular risk, based on the principals of preventive medicine.

原文English
頁(從 - 到)1-6
頁數6
期刊Drug and Alcohol Dependence
180
DOIs
出版狀態Published - 2017 十一月 1

指紋

Areca
Mastication
Vascular Stiffness
Stiffness
Odds Ratio
Confidence Intervals
Pulse Wave Analysis
Preventive Medicine
Hypoglycemic Agents
Regression analysis
Antihypertensive Agents
Medicine
Habits
Logistics
Coronary Artery Disease
Atherosclerosis
Logistic Models
Regression Analysis
Lipids

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

引用此文

@article{042adcf00d494d38a57faf0403cc9e8a,
title = "Betel nut chewing associated with increased risk of arterial stiffness",
abstract = "Background Betel nut chewing is associated with certain cardiovascular outcomes. Subclinical atherosclerosis may be one link between betel nut chewing and cardiovascular risk. Few studies have examined the association between chewing betel nut and arterial stiffness. The aim of this study was thus to determine the relationship between betel nut chewing and arterial stiffness in a Taiwanese population. Methods We enrolled 7540 eligible subjects in National Cheng Kung University Hospital from October 2006 to August 2009. The exclusion criteria included history of cerebrovascular events, coronary artery disease, and taking lipid-lowering drugs, antihypertensives, and hypoglycemic agents. Increased arterial stiffness was defined as brachial–ankle pulse wave velocity (baPWV) ≥1400 cm/s. According to their habit of betel nut use, the subjects were categorized into non-, ex-, and current chewers. Results The prevalence of increased arterial stiffness was 32.7, 43.3, and 43.2{\%} in non-, ex- and current chewers, respectively (p = 0.011). Multiple logistic regression analysis revealed that ex-chewers (odds ratio [OR] 1.69, 95{\%} confidence interval (CI) = 1.08–2.65) and current chewers (OR 2.29, 95{\%} CI = 1.05–4.99) had elevated risks of increased arterial stiffness after adjustment for co-variables. Conclusions Both ex- and current betel nut chewing were associated with a higher risk of increased arterial stiffness. Stopping betel nut chewing may thus potentially be beneficial to reduce cardiovascular risk, based on the principals of preventive medicine.",
author = "Wei, {Yu Ting} and Chou, {Yu Tsung} and Yang, {Yi Ching} and Chou, {Chieh Ying} and Lu, {Feng Hwa} and Chang, {Chih Jen} and Wu, {Jin Shang}",
year = "2017",
month = "11",
day = "1",
doi = "10.1016/j.drugalcdep.2017.07.035",
language = "English",
volume = "180",
pages = "1--6",
journal = "Drug and Alcohol Dependence",
issn = "0376-8716",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Betel nut chewing associated with increased risk of arterial stiffness

AU - Wei, Yu Ting

AU - Chou, Yu Tsung

AU - Yang, Yi Ching

AU - Chou, Chieh Ying

AU - Lu, Feng Hwa

AU - Chang, Chih Jen

AU - Wu, Jin Shang

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Background Betel nut chewing is associated with certain cardiovascular outcomes. Subclinical atherosclerosis may be one link between betel nut chewing and cardiovascular risk. Few studies have examined the association between chewing betel nut and arterial stiffness. The aim of this study was thus to determine the relationship between betel nut chewing and arterial stiffness in a Taiwanese population. Methods We enrolled 7540 eligible subjects in National Cheng Kung University Hospital from October 2006 to August 2009. The exclusion criteria included history of cerebrovascular events, coronary artery disease, and taking lipid-lowering drugs, antihypertensives, and hypoglycemic agents. Increased arterial stiffness was defined as brachial–ankle pulse wave velocity (baPWV) ≥1400 cm/s. According to their habit of betel nut use, the subjects were categorized into non-, ex-, and current chewers. Results The prevalence of increased arterial stiffness was 32.7, 43.3, and 43.2% in non-, ex- and current chewers, respectively (p = 0.011). Multiple logistic regression analysis revealed that ex-chewers (odds ratio [OR] 1.69, 95% confidence interval (CI) = 1.08–2.65) and current chewers (OR 2.29, 95% CI = 1.05–4.99) had elevated risks of increased arterial stiffness after adjustment for co-variables. Conclusions Both ex- and current betel nut chewing were associated with a higher risk of increased arterial stiffness. Stopping betel nut chewing may thus potentially be beneficial to reduce cardiovascular risk, based on the principals of preventive medicine.

AB - Background Betel nut chewing is associated with certain cardiovascular outcomes. Subclinical atherosclerosis may be one link between betel nut chewing and cardiovascular risk. Few studies have examined the association between chewing betel nut and arterial stiffness. The aim of this study was thus to determine the relationship between betel nut chewing and arterial stiffness in a Taiwanese population. Methods We enrolled 7540 eligible subjects in National Cheng Kung University Hospital from October 2006 to August 2009. The exclusion criteria included history of cerebrovascular events, coronary artery disease, and taking lipid-lowering drugs, antihypertensives, and hypoglycemic agents. Increased arterial stiffness was defined as brachial–ankle pulse wave velocity (baPWV) ≥1400 cm/s. According to their habit of betel nut use, the subjects were categorized into non-, ex-, and current chewers. Results The prevalence of increased arterial stiffness was 32.7, 43.3, and 43.2% in non-, ex- and current chewers, respectively (p = 0.011). Multiple logistic regression analysis revealed that ex-chewers (odds ratio [OR] 1.69, 95% confidence interval (CI) = 1.08–2.65) and current chewers (OR 2.29, 95% CI = 1.05–4.99) had elevated risks of increased arterial stiffness after adjustment for co-variables. Conclusions Both ex- and current betel nut chewing were associated with a higher risk of increased arterial stiffness. Stopping betel nut chewing may thus potentially be beneficial to reduce cardiovascular risk, based on the principals of preventive medicine.

UR - http://www.scopus.com/inward/record.url?scp=85028576854&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028576854&partnerID=8YFLogxK

U2 - 10.1016/j.drugalcdep.2017.07.035

DO - 10.1016/j.drugalcdep.2017.07.035

M3 - Article

C2 - 28850901

AN - SCOPUS:85028576854

VL - 180

SP - 1

EP - 6

JO - Drug and Alcohol Dependence

JF - Drug and Alcohol Dependence

SN - 0376-8716

ER -