Betel nut chewing associated with increased risk of arterial stiffness

Yu Ting Wei, Yu Tsung Chou, Yi Ching Yang, Chieh Ying Chou, Feng Hwa Lu, Chih Jen Chang, Jin Shang Wu

研究成果: Article同行評審

17 引文 斯高帕斯(Scopus)


Background Betel nut chewing is associated with certain cardiovascular outcomes. Subclinical atherosclerosis may be one link between betel nut chewing and cardiovascular risk. Few studies have examined the association between chewing betel nut and arterial stiffness. The aim of this study was thus to determine the relationship between betel nut chewing and arterial stiffness in a Taiwanese population. Methods We enrolled 7540 eligible subjects in National Cheng Kung University Hospital from October 2006 to August 2009. The exclusion criteria included history of cerebrovascular events, coronary artery disease, and taking lipid-lowering drugs, antihypertensives, and hypoglycemic agents. Increased arterial stiffness was defined as brachial–ankle pulse wave velocity (baPWV) ≥1400 cm/s. According to their habit of betel nut use, the subjects were categorized into non-, ex-, and current chewers. Results The prevalence of increased arterial stiffness was 32.7, 43.3, and 43.2% in non-, ex- and current chewers, respectively (p = 0.011). Multiple logistic regression analysis revealed that ex-chewers (odds ratio [OR] 1.69, 95% confidence interval (CI) = 1.08–2.65) and current chewers (OR 2.29, 95% CI = 1.05–4.99) had elevated risks of increased arterial stiffness after adjustment for co-variables. Conclusions Both ex- and current betel nut chewing were associated with a higher risk of increased arterial stiffness. Stopping betel nut chewing may thus potentially be beneficial to reduce cardiovascular risk, based on the principals of preventive medicine.

頁(從 - 到)1-6
期刊Drug and Alcohol Dependence
出版狀態Published - 2017 11月 1

All Science Journal Classification (ASJC) codes

  • 毒理學
  • 藥理
  • 精神病學和心理健康
  • 藥學(醫學)


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