Bioactive chemical constituents from the root bark of Morus australis

Yu Ren Liao, Ping Chung Kuo, Wei Jern Tsai, Guan Jhong Huang, Kuo Hsiung Lee, Tian Shung Wu

研究成果: Article同行評審

13 引文 斯高帕斯(Scopus)

摘要

Two new pyranoflavonoids, morustralins A (1) and B (2), a new natural benzene derivative, one benzenoid (Z)-1-hydroxy-4-(2-nitroethenyl)benzene (3), and thirty known compounds were isolated and characterized from the root bark of Morus australis. The structures of the new compounds were established from spectroscopic and spectrometric analyses. Ten isolates (1–10) were examined for inhibitory effects on adenosine diphosphate (ADP)-, arachidonic acid (AA)-, and platelet-aggregating factor (PAF)-induced platelet aggregation. Among the tested compounds, compound 3 displayed the most significant inhibition of ADP- and AA-induced platelet aggregation with IC50values of 9.76 ± 5.54 and 9.81 ± 2.7 μM, respectively. In addition, eight purified compounds (3–10) were examined for inhibition of nitric oxide (NO) production in RAW 264.7 cells and six compounds (3–8) displayed significant inhibitory effects with IC50values ranging from 2.1 ± 0.3 to 6.3 ± 0.6 μM.

原文English
頁(從 - 到)309-313
頁數5
期刊Bioorganic and Medicinal Chemistry Letters
27
發行號2
DOIs
出版狀態Published - 2017

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 分子醫學
  • 分子生物學
  • 藥學科學
  • 藥物發現
  • 臨床生物化學
  • 有機化學

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