Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of: Fomitopsis pinicola and their anti-inflammatory activity

Shih Huang Tai, Ping Chung Kuo, Ching Che Hung, Ying Hsuan Lin, Tsong Long Hwang, Sio Hong Lam, Daih Huang Kuo, Jin Bin Wu, Hsin Yi Hung, Tian Shung Wu

研究成果: Article

摘要

Twelve undescribed sesquiterpenoids, fomitopins A-L (1-12), were isolated via bioassay-guided purification from the bracket fungus Fomitopsis pinicola (Sw.) P. Karst, and this fungus have been reported to exhibit anti-microbial and anti-inflammatory activities. The structures of 1-12 were elucidated by spectroscopic and spectrometric analyses and their absolute configurations were further confirmed by ECD simulations. Ten isolated compounds were evaluated for their anti-inflammatory potential and compound 11 exhibited the most significant inhibition of superoxide anion generation and elastase release with IC50 values of 0.81 ± 0.15 and 0.74 ± 0.12 μM. These newly purified sesquiterpenoids could be potential candidates for further anti-inflammatory studies.

原文English
頁(從 - 到)34184-34195
頁數12
期刊RSC Advances
9
發行號59
DOIs
出版狀態Published - 2019 一月 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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