TY - JOUR
T1 - Biodegradation ZK50 magnesium alloy compression screws
T2 - Mechanical properties, biodegradable characteristics and implant test
AU - Chen, Yen Ting
AU - Hung, Fei Yi
AU - Lin, Yen Ling
AU - Lin, Chia Yen
N1 - Funding Information:
The authors are grateful to the Instrument Center of National Cheng Kung University and the Ministry of Science and Technology of Taiwan ( MOST 107-2221-E−006-012-MY2 ) for their financial support. The grants details which working under consideration for publication from the Ministry of Science and Technology of Taiwan are shown as follows: NTD $200,000 to Fei-Yi Hung, NTD $50,000 to Yen-Ting Chen and NTD $50,000 to Chia-Yen Lin.
Publisher Copyright:
© 2020 The Japanese Orthopaedic Association
PY - 2020/11
Y1 - 2020/11
N2 - Background: Magnesium alloy implants have lower stress load and can be absorbed gradually, but their degradation rates are too fast generally. A magnesium alloy contained 5% Zn and 0.5% Zr (ZK50) which have lower degradation rate are designed to be applied to cannulated bone screw. Methods: An oxidation heat treatment of 380 °C for 2 h proceeds to modify the ZK50 Mg alloy (ZK50-H). The microstructure observation, degradation tests and Biocompatibility analysis are proceeded between ZK50 and ZK50-H. Finally, a mini-pig implantation test is proceeded to provide a reference of implant application for future pre-clinical evaluation. Results: The heat treatment can improve the mechanical properties. A passive ceramic layer formed after simulated body fluid (SBF) solution immersion can restrict the degradation effectively. The cytotoxicity test shows the initial biosafety of ZK50 Mg alloy. A mini-pig implantation test of bone screw has proceeded to confirm the advanced biocompatibility. The ZK50-H screws can maintain enough support at least 8 weeks which the fracture of bone can get curing. The excellent osteoinduction of ZK50-H has a positive effect to growth of new bones and help the mini-pig regain heal faster in 12 weeks. Conclusion: This study shows ZK50-H Mg alloy screw is a feasible degradation implant and can be carried out the next-step clinical experiments.
AB - Background: Magnesium alloy implants have lower stress load and can be absorbed gradually, but their degradation rates are too fast generally. A magnesium alloy contained 5% Zn and 0.5% Zr (ZK50) which have lower degradation rate are designed to be applied to cannulated bone screw. Methods: An oxidation heat treatment of 380 °C for 2 h proceeds to modify the ZK50 Mg alloy (ZK50-H). The microstructure observation, degradation tests and Biocompatibility analysis are proceeded between ZK50 and ZK50-H. Finally, a mini-pig implantation test is proceeded to provide a reference of implant application for future pre-clinical evaluation. Results: The heat treatment can improve the mechanical properties. A passive ceramic layer formed after simulated body fluid (SBF) solution immersion can restrict the degradation effectively. The cytotoxicity test shows the initial biosafety of ZK50 Mg alloy. A mini-pig implantation test of bone screw has proceeded to confirm the advanced biocompatibility. The ZK50-H screws can maintain enough support at least 8 weeks which the fracture of bone can get curing. The excellent osteoinduction of ZK50-H has a positive effect to growth of new bones and help the mini-pig regain heal faster in 12 weeks. Conclusion: This study shows ZK50-H Mg alloy screw is a feasible degradation implant and can be carried out the next-step clinical experiments.
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U2 - 10.1016/j.jos.2020.01.018
DO - 10.1016/j.jos.2020.01.018
M3 - Article
C2 - 32220468
AN - SCOPUS:85082192732
VL - 25
SP - 1107
EP - 1115
JO - Journal of Orthopaedic Science
JF - Journal of Orthopaedic Science
SN - 0949-2658
IS - 6
ER -