Biofriendly chitosan-based high-efficiency dialysis membrane

Shih Chen Shi, Yu Wen Chang

研究成果: Article同行評審


Chitosan, a biofriendly material, has a wide range of applications owing to its biocompatibility and biodegradability. We successfully prepared super-adsorbent membranes by dip-coating filter paper in chemically and physically modified chitosan solutions, and compared the urea adsorption performances of the different chitosan membranes. Chemical modification was achieved by successfully introducing carboxyl and amine groups into chitosan by carboxylation and amination using chloroacetic acid (ClCHCOH) and ethylenediamine (C2H4(NH2)2), respectively. Physical modification was performed by attempting different crosslinking reactions using sodium tripolyphosphate and copper ions (Cu2+). The effects of the various physical and chemical modifications was determined on the urea reduction ratio (URR). At a urea concentration of 500 ppm, the modified chitosan membranes exhibited URRs of >80 % within 2 h, a 38 % decrease in the equilibrium swelling ratio, and a 600 % increase in the bursting strength. These results demonstrate the immense potential of these membranes for hemodialysis in biomedical research. Lastly, model fitting revealed that the mechanisms of urea adsorption onto chitosan were best described using the Freundlich adsorption isotherm and the pseudo-second-order kinetic model.

期刊Progress in Organic Coatings
出版狀態Published - 2022 9月

All Science Journal Classification (ASJC) codes

  • 化學工程 (全部)
  • 表面、塗料和薄膜
  • 有機化學
  • 材料化學


深入研究「Biofriendly chitosan-based high-efficiency dialysis membrane」主題。共同形成了獨特的指紋。