Biomechanical stability and biological effect of titanium intramedullary implant in rabbit femur with the filler of fast-setting calcium phosphate cement

D. J. Lin, J. H. ChernLin, C. P. Ju, W. C. Chen, S. H. Huang, Y. C. Tien

研究成果: Conference contribution

摘要

This in vivo study evaluated the biomechanical stability and biological effects of titanium implant with the filler of fast-setting calcium phosphate cement (CPC) and polymethyl methacrylate (PMMA) as a retarder. Histological and biomechanical studies were conducted in New Zealand white rabbits to evaluate the effects of CPC on bone formation around a titanium rod in femoral bone marrow. The animals received injections of CPC into the femoral bone marrow from the distal end of the right femur, where a titanium rod was inserted bilaterally. The titanium rod being inserted without cement in the left femur was the control group. Four rabbits were sacrificed for pullout test and two for obtained histological samples at 1st, 4th, 12th, 26th and 70th postoperative week (total n=30). On mechanical evaluation, titanium rod implanted with CPC showed significant differences in maximum pullout force at week 4 and week 12 comparing with the control groups. On the examination of decalcified specimens, at week 1, new bone formation around titanium implant was clearly identified in CPC group, on the contrary, fibrous stroma in the control group and necrosis in PMMA sections were found around titanium implants. Residual CPC separates into pieces and was found in peripheral bone at week 12, and chronic inflammation was found around PMMA at week 4 and 12. These results suggest that the fast-setting CPC filled bone defects around the rod and promoted bone formation at a relatively early stage.

原文English
主出版物標題World Congress on Medical Physics and Biomedical Engineering
主出版物子標題Biomaterials, Cellular and Tissue Engineering, Artificial Organs
頁面270-273
頁數4
版本10
DOIs
出版狀態Published - 2009 十二月 1
事件World Congress on Medical Physics and Biomedical Engineering: Biomaterials, Cellular and Tissue Engineering, Artificial Organs - Munich, Germany
持續時間: 2009 九月 72009 九月 12

出版系列

名字IFMBE Proceedings
號碼10
25
ISSN(列印)1680-0737

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Biomaterials, Cellular and Tissue Engineering, Artificial Organs
國家Germany
城市Munich
期間09-09-0709-09-12

    指紋

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

引用此

Lin, D. J., ChernLin, J. H., Ju, C. P., Chen, W. C., Huang, S. H., & Tien, Y. C. (2009). Biomechanical stability and biological effect of titanium intramedullary implant in rabbit femur with the filler of fast-setting calcium phosphate cement. 於 World Congress on Medical Physics and Biomedical Engineering: Biomaterials, Cellular and Tissue Engineering, Artificial Organs (10 編輯, 頁 270-273). (IFMBE Proceedings; 卷 25, 編號 10). https://doi.org/10.1007/978-3-642-03900-3-78