Biomimetic hydrogels based on L-Dopa conjugated gelatin as pH-responsive drug carriers and antimicrobial agents

Thi Ngoc Pham, Ching Fang Su, Ching Chia Huang, Jeng Shiung Jan

研究成果: Article同行評審

31 引文 斯高帕斯(Scopus)

摘要

Biomimetic hydrogels which possess good biocompatibility, high degradability, and low toxicity as well as good antibacterial activity against various bacteria would potentially be promising for biomaterial applications, such as wound healing, tissue engineering, and payload delivery systems. Herein, we report the synthesis and hydrogelation of L-Dopa conjugated (GPLD) polypeptides via a versatile strategy including enzymatic cross-linking or coordinated/oxidized cross-linking with Fe3+ ions and demonstrated the feasibility of loading cancer drug and metal NPs in hydrogel matrix. The drug-loaded hydrogel was simply prepared via coordinated/oxidized cross-linking by Fe3+ and H2O2 within short gelation time. Doxorubicin (DOX) was encapsulated in the hydrogel network through the formation of metal-DOX/catechol complexes. The catechol groups acted not only as the complexing depots for DOX encapsulation but also as cross-linking depots for hydrogel formation. The mechanical strength, swelling ratio, and degradability behavior could be tuned by varying Fe3+/H2O2 or enzyme/H2O2 concentration. The as-prepared hydrogel exhibited excellent pH-responsive drug release behavior and the ability to effectively kill cancer cells by pH-triggered release of DOX. We also demonstrated that the enzymatically cross-linked hydrogels loaded with metal nanoparticles (NPs) exhibiting excellent antimicrobial activities. This multifunctional hydrogel is promising for drug delivery and antimicrobial applications.

原文English
文章編號111316
期刊Colloids and Surfaces B: Biointerfaces
196
DOIs
出版狀態Published - 2020 12月

All Science Journal Classification (ASJC) codes

  • 生物技術
  • 表面和介面
  • 物理與理論化學
  • 膠體和表面化學

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