Biomimicking Platelet–Monocyte Interactions as a Novel Targeting Strategy for Heart Healing

Bill Cheng, Elsie K.W. Toh, Kun Hung Chen, Yuan Chih Chang, Che Ming J. Hu, Han Chung Wu, Lee Young Chau, Peilin Chen, Patrick C.H. Hsieh

研究成果: Article同行評審

6 引文 斯高帕斯(Scopus)

摘要

In patients who survive myocardial infarction, many go on to develop congestive heart failure (CHF). Despite ongoing efforts to develop new approaches for postinfarction therapy, there are still no effective therapeutic options available to CHF patients. Currently, the delivery of cardioprotective drugs relies entirely on passive uptake via the enhanced permeability and retention (EPR) effect which occurs in proximity to the infarction site. However, in ischemic disease, unlike in cancer, the EPR effect only exists for a short duration postinfarction and thus insufficient for meaningful cardioprotection. Splenic monocytes are recruited to the heart in large numbers postinfarction, and are known to interact with platelets during circulation. Therefore, the strategy is to exploit this interaction by developing platelet-like proteoliposomes (PLPs), biomimicking platelet interactions with circulating monocytes. PLPs show strong binding affinity for monocytes but not for endothelial cells in vitro, mimicking normal platelet activity. Furthermore, intravital multiphoton imaging shows that comparing to plain liposomes, PLPs do not aggregate on uninjured endothelium but do accumulate at the injury site 72 h postinfarction. Importantly, PLPs enhance the targeting of anti-inflammatory drug, cobalt protoporphyrin, to the heart in an EPR-independent manner, which result in better therapeutic outcome.

原文English
頁(從 - 到)2686-2697
頁數12
期刊Advanced Healthcare Materials
5
發行號20
DOIs
出版狀態Published - 2016 十月 26

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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