Biosignaling of mammalian Ste20-related kinases

Pin Ling, Te Jung Lu, Chiun Jye Yuan, Ming Derg Lai

研究成果: Review article

100 引文 (Scopus)

摘要

Sterile 20 (ste20) protein is an upstream ser/thr kinase in yeast, and several mammalian Ste20-like (MST) kinases have been identified. This review focuses on the signal transduction, interacting proteins, and potential biological function of MST1, 2, 3, and 4 kinases, since several novel signal pathways of these kinases have been characterized recently. MST1 and MST2 kinases play an important role in cell growth and apoptosis, and the signal pathways involves many important molecules including RAS, AKT, and FOXO3. MST3 and MST4 have similar kinase domain, but have opposite effects on apoptosis and transformation. The downstream signaling molecules of these two kinases are beginning to be elucidated. Based on the expression pattern and signal pathways, we will discuss the perspective biological functions of four MST family kinases in cancer, immune, cardiovascular, and brain function.

原文English
頁(從 - 到)1237-1247
頁數11
期刊Cellular Signalling
20
發行號7
DOIs
出版狀態Published - 2008 七月 1

指紋

Phosphotransferases
Signal Transduction
Apoptosis
Proteins
Yeasts
Brain
Growth
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cell Biology

引用此文

Ling, Pin ; Lu, Te Jung ; Yuan, Chiun Jye ; Lai, Ming Derg. / Biosignaling of mammalian Ste20-related kinases. 於: Cellular Signalling. 2008 ; 卷 20, 編號 7. 頁 1237-1247.
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Biosignaling of mammalian Ste20-related kinases. / Ling, Pin; Lu, Te Jung; Yuan, Chiun Jye; Lai, Ming Derg.

於: Cellular Signalling, 卷 20, 編號 7, 01.07.2008, p. 1237-1247.

研究成果: Review article

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