TY - JOUR
T1 - Biosignaling of mammalian Ste20-related kinases
AU - Ling, Pin
AU - Lu, Te Jung
AU - Yuan, Chiun Jye
AU - Lai, Ming Derg
N1 - Funding Information:
This work is in part supported by the Grant NSC 95-2311-B-006-001 to Dr. Ming-Derg Lai from National Science Council, Taiwan, Republic of China.
PY - 2008/7
Y1 - 2008/7
N2 - Sterile 20 (ste20) protein is an upstream ser/thr kinase in yeast, and several mammalian Ste20-like (MST) kinases have been identified. This review focuses on the signal transduction, interacting proteins, and potential biological function of MST1, 2, 3, and 4 kinases, since several novel signal pathways of these kinases have been characterized recently. MST1 and MST2 kinases play an important role in cell growth and apoptosis, and the signal pathways involves many important molecules including RAS, AKT, and FOXO3. MST3 and MST4 have similar kinase domain, but have opposite effects on apoptosis and transformation. The downstream signaling molecules of these two kinases are beginning to be elucidated. Based on the expression pattern and signal pathways, we will discuss the perspective biological functions of four MST family kinases in cancer, immune, cardiovascular, and brain function.
AB - Sterile 20 (ste20) protein is an upstream ser/thr kinase in yeast, and several mammalian Ste20-like (MST) kinases have been identified. This review focuses on the signal transduction, interacting proteins, and potential biological function of MST1, 2, 3, and 4 kinases, since several novel signal pathways of these kinases have been characterized recently. MST1 and MST2 kinases play an important role in cell growth and apoptosis, and the signal pathways involves many important molecules including RAS, AKT, and FOXO3. MST3 and MST4 have similar kinase domain, but have opposite effects on apoptosis and transformation. The downstream signaling molecules of these two kinases are beginning to be elucidated. Based on the expression pattern and signal pathways, we will discuss the perspective biological functions of four MST family kinases in cancer, immune, cardiovascular, and brain function.
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U2 - 10.1016/j.cellsig.2007.12.019
DO - 10.1016/j.cellsig.2007.12.019
M3 - Review article
C2 - 18255267
AN - SCOPUS:43049155951
SN - 0898-6568
VL - 20
SP - 1237
EP - 1247
JO - Cellular Signalling
JF - Cellular Signalling
IS - 7
ER -
