@article{7648584fccc74b5ea7e413bdff3e0521,
title = "Bis(4-glycosyloxybenzyl) 2-isobutyltartrate and dihydrophenanthrene derivatives from the pseudobulbs of Pholidota chinensis and their anti-inflammatory activity",
abstract = "Six previously undescribed components, bis(4-glycosyloxybenzyl) 2-isobutyltartrate derivatives (pholidotoside A-E) and phenolic glycoside (pholidotosin A), together with twenty known compounds were isolated from the pseudobulbs of Pholidota chinensis. Their structures and absolute configuration were elucidated and established through various spectroscopic and chemical methods. The anti-inflammatory potential of selected compounds was examined using a human neutrophil cell model activated by N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB). Among these, dihydrophenanthrenes exhibited potent inhibitory effect on both superoxide anion generation and elastase release assays with IC50 values ranging from 0.41 ± 0.05 to 7.14 ± 0.30 μM.",
author = "Tsai, {Cheng Ming} and Chen, {Chun Yu} and Le, {Phung Kim} and Wang, {Yi Hsuan} and Lam, {Sio Hong}",
note = "Funding Information: The authors are grateful for financial support from the Ministry of Science and Technology (MOST 109-2320-B-006-048-MY3), Taiwan awarded to S.-H. Lam, and Chang Gung Memorial Hospital (CMRPG3K0921 and CMRPG3J1001-3), Taiwan awarded to C.-Y. Chen. This research was also supported in part by Higher Education Sprout Project, Ministry of Education to the Headquarters of University Advancement at National Cheng Kung University (NCKU).Authors are thankful to Hsiao-Ching Yu, the High Valued Instrument Center, National Sun Yat-Sen University, for the mass (MS000600) spectra. The authors gratefully acknowledge the use of NMR0050000 and NMR005700 equipment belonging to the Core Facility Center of National Cheng Kung University, Taiwan; Ministry of Science and Technology, Taiwan; Chang Gung Memorial Hospital, Taiwan; Ministry of Education to the Headquarters of University Advancement at National Cheng Kung University. The Ministry of Science and Technology, Vietnam. Funding Information: The authors are grateful for financial support from the Ministry of Science and Technology ( MOST 109-2320-B-006-048-MY3 ), Taiwan awarded to S.-H. Lam, and Chang Gung Memorial Hospital ( CMRPG3K0921 and CMRPG3J1001-3 ), Taiwan awarded to C.-Y. Chen. This research was also supported in part by Higher Education Sprout Project , Ministry of Education to the Headquarters of University Advancement at National Cheng Kung University (NCKU) . Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",
year = "2023",
month = feb,
doi = "10.1016/j.phytochem.2022.113528",
language = "English",
volume = "206",
journal = "Phytochemistry",
issn = "0031-9422",
publisher = "Elsevier Limited",
}