Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation

Shian Jang Yan, Jeremiah J. Zartman, Minjie Zhang, Anthony Scott, Stanislav Y. Shvartsman, Willis X. Li

研究成果: Article同行評審

19 引文 斯高帕斯(Scopus)

摘要

Cell differentiation in developing tissues is controlled by a small set of signaling pathways, which must coordinate the timing and levels of activation to ensure robust and precise outcomes. Highly coordinated activation of signaling pathways can result from cross-regulatory interactions in multi-pathway networks. Here we explore the dynamics and function of pathway coordination between the EGFR and DPP pathways during Drosophila wing-vein differentiation. We show that simultaneous activation of both the EGFR and DPP pathways must be maintained for vein cell differentiation and that above-threshold ectopic activation of either pathway is sufficient to drive vein cell differentiation outside the proveins. The joint activation of the EGFR and DPP signaling systems is ensured by a positive feedback loop, in which the two pathways stimulate each other at the level of ligand production.

原文English
文章編號278
期刊Molecular Systems Biology
5
DOIs
出版狀態Published - 2009 一月 20

All Science Journal Classification (ASJC) codes

  • 生物化學、遺傳與分子生物學 (全部)
  • 免疫學與微生物學 (全部)
  • 農業與生物科學 (全部)
  • 應用數學

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