摘要
Cell differentiation in developing tissues is controlled by a small set of signaling pathways, which must coordinate the timing and levels of activation to ensure robust and precise outcomes. Highly coordinated activation of signaling pathways can result from cross-regulatory interactions in multi-pathway networks. Here we explore the dynamics and function of pathway coordination between the EGFR and DPP pathways during Drosophila wing-vein differentiation. We show that simultaneous activation of both the EGFR and DPP pathways must be maintained for vein cell differentiation and that above-threshold ectopic activation of either pathway is sufficient to drive vein cell differentiation outside the proveins. The joint activation of the EGFR and DPP signaling systems is ensured by a positive feedback loop, in which the two pathways stimulate each other at the level of ligand production.
原文 | English |
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文章編號 | 278 |
期刊 | Molecular Systems Biology |
卷 | 5 |
DOIs | |
出版狀態 | Published - 2009 1月 20 |
All Science Journal Classification (ASJC) codes
- 資訊系統
- 一般免疫學和微生物學
- 應用數學
- 一般生物化學,遺傳學和分子生物學
- 一般農業與生物科學
- 計算機理論與數學