Bloodstream infections caused by extended-spectrum beta-lactamase-producing escherichia coli in patients with liver cirrhosis

Wen Chi Chen, Chih Hsin Hung, Yao Shen Chen, Jin Shiung Cheng, Susan Shin Jung Lee, Fan Chen Tseng, Ming Fang Cheng, Jiun Ling Wang

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Background: This study aimed to investigate the frequency of sequence type (ST) 131 strains and outcome of cirrhotic patients with bloodstream infections (BSIs) caused by extended-spectrum beta-lactamase-producing Escherichia coli (ESBLEC) and non-extended-spectrum beta-lactamase-producing Escherichia coli (NESBLEC). Methods: The incidence of ST 131 strains, hospital stay, and 30-day re-admission/mortality were compared between 51 ESBLEC and 51 NESBLEC bacteremic patients with cirrhosis. Results: ST 131 strains were found in 35.3% of the ESBLEC group and 0% of the NESBLEC group (p < 0.001). Mean hospital stay was 26.5 days in the ESBLEC group and 17.1 days in the NESBLEC group (p = 0.006). Thirty-day re-admission rates were 11.8% in the ESBLEC group and 5.9% in the NESBLEC group (p = 0.5). ST 131 strains were associated with 30-day re-admission (odds ratio: 4.5, 95% confidence interval: 1.1–18.9). Thirty-day mortality rate was 31.4% in the ESBLEC group and 23.5% in the NESBLEC group (p = 0.4). Conclusion: In patients with cirrhosis, the ESBLEC BSIs group had a higher frequency of ST 131 strains and longer hospital stay than the NESBLEC BSIs group with similar 30-day re-admission/mortality. ST 131 strains were associated with 30-day re-admission.

原文English
文章編號37
頁(從 - 到)1-13
頁數13
期刊Pathogens
10
發行號1
DOIs
出版狀態Published - 2021 一月

All Science Journal Classification (ASJC) codes

  • 免疫學和過敏
  • 分子生物學
  • 免疫學與微生物學 (全部)
  • 微生物學(醫學)
  • 傳染性疾病

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