Border-cell migration requires integration of spatial and temporal signals by the BTB protein Abrupt

Chuen-Chuen Jang, Yu Chiuan Chang, Jianwu Bai, Denise Montell

研究成果: Article

65 引文 (Scopus)

摘要

During development, elaborate patterns of cell differentiation and movement must occur in the correct locations and at the proper times. Developmental timing has been studied less than spatial pattern formation, and the mechanisms integrating the two are poorly understood. Border-cell migration in the Drosophila ovary occurs specifically at stage 9. Timing of the migration is regulated by the steroid hormone ecdysone, whereas spatial patterning of the migratory population requires localized activity of the JAK-STAT pathway. Ecdysone signalling is patterned spatially as well as temporally, although the mechanisms are not well understood. In stage 9 egg chambers, ecdysone signalling is highest in anterior follicle cells including the border cells. We identify the gene abrupt as a repressor of ecdysone signalling and border-cell migration. Abrupt protein is normally lost from border-cell nuclei during stage 9, in response to JAK-STAT activity. This contributes to the spatial pattern of the ecdysone response. Abrupt attenuates ecdysone signalling by means of a direct interaction with the basic helix-loop-helix (bHLH) domain of the P160 ecdysone receptor coactivator Taiman (Tai). Taken together, these findings provide a molecular mechanism by which spatial and temporal cues are integrated.

原文English
頁(從 - 到)569-579
頁數11
期刊Nature Cell Biology
11
發行號5
DOIs
出版狀態Published - 2009 四月 7

指紋

Ecdysone
Cell Movement
Proteins
Helix-Loop-Helix Motifs
Cell Nucleus
Drosophila
Cues
Ovum
Cell Differentiation
Ovary
Steroids
Hormones
Population
Genes

All Science Journal Classification (ASJC) codes

  • Cell Biology

引用此文

Jang, Chuen-Chuen ; Chang, Yu Chiuan ; Bai, Jianwu ; Montell, Denise. / Border-cell migration requires integration of spatial and temporal signals by the BTB protein Abrupt. 於: Nature Cell Biology. 2009 ; 卷 11, 編號 5. 頁 569-579.
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Border-cell migration requires integration of spatial and temporal signals by the BTB protein Abrupt. / Jang, Chuen-Chuen; Chang, Yu Chiuan; Bai, Jianwu; Montell, Denise.

於: Nature Cell Biology, 卷 11, 編號 5, 07.04.2009, p. 569-579.

研究成果: Article

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