Breast cancer detection of large size to DCIS by hypoxia and angiogenesis using NIRS

Shoko Nioka, Mitch Shnall, Emily Conant, Shih Chang Wang, Visjna Baksa Reynolds, Boon Chye Ching, Juliana Ho Teng Swan, Pau-Choo Chung, Li-Li Cheng, Dar-Bin Shieh, Yungchi Lin, Chenghung Chung, Sheng-Hao Tseng, Britton Chance

研究成果: Conference contribution

摘要

This investigation aimed to test all tumor-bearing patients who undergo biopsy to see if angiogenesis and hypoxia can detect cancer. We used continuous-wave near-infrared spectroscopy (NIRS) to measure blood hemoglobin concentration to obtain blood volume or total hemoglobin [Hbtot] and oxygen saturation for the angiogenesis and hypoxic biomarkers. The contralateral breast was used as a reference to derive the difference from breast tumor as a difference in total hemoglobin Δ[HBtot] and a difference in deoxygenation Δ([Hb]-[HbO2]). A total of 91 invasive cancers, 26 DCIS, 45 fibroblastomas, 96 benign tumors excluding cysts, and 67 normal breasts were examined from four hospitals. In larger-size tumors, there is significantly higher deoxygenation in invasive and ductal carcinoma in situ (DCIS) than in that of benign tumors, but no significant difference was seen in smaller tumors of ≤ 1 cm. With the two parameters of high total hemoglobin and hypoxia score, the sensitivity and specificity of cancer detection were 60.3 % and 85.3 %, respectively. In summary, smaller-size tumors are difficult to detect with NIRS, whereas DCIS can be detected by the same total hemoglobin and hypoxic score in our study.

原文English
主出版物標題Oxygen Transport to Tissue XXXV
發行者Springer New York LLC
頁面211-219
頁數9
ISBN(列印)9781461472568
DOIs
出版狀態Published - 2013 一月 1

出版系列

名字Advances in Experimental Medicine and Biology
789
ISSN(列印)0065-2598

指紋

Carcinoma, Intraductal, Noninfiltrating
Near infrared spectroscopy
Near-Infrared Spectroscopy
Tumors
Breast Neoplasms
Hemoglobins
Neoplasms
Blood
Bearings (structural)
Breast
Biopsy
Biomarkers
Hypoxia
Blood Volume
Oxygen
Cysts
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

引用此文

Nioka, S., Shnall, M., Conant, E., Wang, S. C., Reynolds, V. B., Ching, B. C., ... Chance, B. (2013). Breast cancer detection of large size to DCIS by hypoxia and angiogenesis using NIRS. 於 Oxygen Transport to Tissue XXXV (頁 211-219). (Advances in Experimental Medicine and Biology; 卷 789). Springer New York LLC. https://doi.org/10.1007/978-1-4614-7411-1_29
Nioka, Shoko ; Shnall, Mitch ; Conant, Emily ; Wang, Shih Chang ; Reynolds, Visjna Baksa ; Ching, Boon Chye ; Swan, Juliana Ho Teng ; Chung, Pau-Choo ; Cheng, Li-Li ; Shieh, Dar-Bin ; Lin, Yungchi ; Chung, Chenghung ; Tseng, Sheng-Hao ; Chance, Britton. / Breast cancer detection of large size to DCIS by hypoxia and angiogenesis using NIRS. Oxygen Transport to Tissue XXXV. Springer New York LLC, 2013. 頁 211-219 (Advances in Experimental Medicine and Biology).
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abstract = "This investigation aimed to test all tumor-bearing patients who undergo biopsy to see if angiogenesis and hypoxia can detect cancer. We used continuous-wave near-infrared spectroscopy (NIRS) to measure blood hemoglobin concentration to obtain blood volume or total hemoglobin [Hbtot] and oxygen saturation for the angiogenesis and hypoxic biomarkers. The contralateral breast was used as a reference to derive the difference from breast tumor as a difference in total hemoglobin Δ[HBtot] and a difference in deoxygenation Δ([Hb]-[HbO2]). A total of 91 invasive cancers, 26 DCIS, 45 fibroblastomas, 96 benign tumors excluding cysts, and 67 normal breasts were examined from four hospitals. In larger-size tumors, there is significantly higher deoxygenation in invasive and ductal carcinoma in situ (DCIS) than in that of benign tumors, but no significant difference was seen in smaller tumors of ≤ 1 cm. With the two parameters of high total hemoglobin and hypoxia score, the sensitivity and specificity of cancer detection were 60.3 {\%} and 85.3 {\%}, respectively. In summary, smaller-size tumors are difficult to detect with NIRS, whereas DCIS can be detected by the same total hemoglobin and hypoxic score in our study.",
author = "Shoko Nioka and Mitch Shnall and Emily Conant and Wang, {Shih Chang} and Reynolds, {Visjna Baksa} and Ching, {Boon Chye} and Swan, {Juliana Ho Teng} and Pau-Choo Chung and Li-Li Cheng and Dar-Bin Shieh and Yungchi Lin and Chenghung Chung and Sheng-Hao Tseng and Britton Chance",
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Nioka, S, Shnall, M, Conant, E, Wang, SC, Reynolds, VB, Ching, BC, Swan, JHT, Chung, P-C, Cheng, L-L, Shieh, D-B, Lin, Y, Chung, C, Tseng, S-H & Chance, B 2013, Breast cancer detection of large size to DCIS by hypoxia and angiogenesis using NIRS. 於 Oxygen Transport to Tissue XXXV. Advances in Experimental Medicine and Biology, 卷 789, Springer New York LLC, 頁 211-219. https://doi.org/10.1007/978-1-4614-7411-1_29

Breast cancer detection of large size to DCIS by hypoxia and angiogenesis using NIRS. / Nioka, Shoko; Shnall, Mitch; Conant, Emily; Wang, Shih Chang; Reynolds, Visjna Baksa; Ching, Boon Chye; Swan, Juliana Ho Teng; Chung, Pau-Choo; Cheng, Li-Li; Shieh, Dar-Bin; Lin, Yungchi; Chung, Chenghung; Tseng, Sheng-Hao; Chance, Britton.

Oxygen Transport to Tissue XXXV. Springer New York LLC, 2013. p. 211-219 (Advances in Experimental Medicine and Biology; 卷 789).

研究成果: Conference contribution

TY - GEN

T1 - Breast cancer detection of large size to DCIS by hypoxia and angiogenesis using NIRS

AU - Nioka, Shoko

AU - Shnall, Mitch

AU - Conant, Emily

AU - Wang, Shih Chang

AU - Reynolds, Visjna Baksa

AU - Ching, Boon Chye

AU - Swan, Juliana Ho Teng

AU - Chung, Pau-Choo

AU - Cheng, Li-Li

AU - Shieh, Dar-Bin

AU - Lin, Yungchi

AU - Chung, Chenghung

AU - Tseng, Sheng-Hao

AU - Chance, Britton

PY - 2013/1/1

Y1 - 2013/1/1

N2 - This investigation aimed to test all tumor-bearing patients who undergo biopsy to see if angiogenesis and hypoxia can detect cancer. We used continuous-wave near-infrared spectroscopy (NIRS) to measure blood hemoglobin concentration to obtain blood volume or total hemoglobin [Hbtot] and oxygen saturation for the angiogenesis and hypoxic biomarkers. The contralateral breast was used as a reference to derive the difference from breast tumor as a difference in total hemoglobin Δ[HBtot] and a difference in deoxygenation Δ([Hb]-[HbO2]). A total of 91 invasive cancers, 26 DCIS, 45 fibroblastomas, 96 benign tumors excluding cysts, and 67 normal breasts were examined from four hospitals. In larger-size tumors, there is significantly higher deoxygenation in invasive and ductal carcinoma in situ (DCIS) than in that of benign tumors, but no significant difference was seen in smaller tumors of ≤ 1 cm. With the two parameters of high total hemoglobin and hypoxia score, the sensitivity and specificity of cancer detection were 60.3 % and 85.3 %, respectively. In summary, smaller-size tumors are difficult to detect with NIRS, whereas DCIS can be detected by the same total hemoglobin and hypoxic score in our study.

AB - This investigation aimed to test all tumor-bearing patients who undergo biopsy to see if angiogenesis and hypoxia can detect cancer. We used continuous-wave near-infrared spectroscopy (NIRS) to measure blood hemoglobin concentration to obtain blood volume or total hemoglobin [Hbtot] and oxygen saturation for the angiogenesis and hypoxic biomarkers. The contralateral breast was used as a reference to derive the difference from breast tumor as a difference in total hemoglobin Δ[HBtot] and a difference in deoxygenation Δ([Hb]-[HbO2]). A total of 91 invasive cancers, 26 DCIS, 45 fibroblastomas, 96 benign tumors excluding cysts, and 67 normal breasts were examined from four hospitals. In larger-size tumors, there is significantly higher deoxygenation in invasive and ductal carcinoma in situ (DCIS) than in that of benign tumors, but no significant difference was seen in smaller tumors of ≤ 1 cm. With the two parameters of high total hemoglobin and hypoxia score, the sensitivity and specificity of cancer detection were 60.3 % and 85.3 %, respectively. In summary, smaller-size tumors are difficult to detect with NIRS, whereas DCIS can be detected by the same total hemoglobin and hypoxic score in our study.

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U2 - 10.1007/978-1-4614-7411-1_29

DO - 10.1007/978-1-4614-7411-1_29

M3 - Conference contribution

C2 - 23852497

AN - SCOPUS:84934440928

SN - 9781461472568

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Nioka S, Shnall M, Conant E, Wang SC, Reynolds VB, Ching BC 等. Breast cancer detection of large size to DCIS by hypoxia and angiogenesis using NIRS. 於 Oxygen Transport to Tissue XXXV. Springer New York LLC. 2013. p. 211-219. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-7411-1_29