Breast cancer detection of large size to DCIS by hypoxia and angiogenesis using NIRS

Shoko Nioka, Mitch Shnall, Emily Conant, Shih Chang Wang, Visjna Baksa Reynolds, Boon Chye Ching, Juliana Ho Teng Swan, Pau Choo Chung, Lili Cheng, Darbin Shieh, Yungchi Lin, Chenghung Chung, Sheng Hao Tseng, Britton Chance

研究成果: Article

摘要

This investigation aimed to test all tumor-bearing patients who undergo biopsy to see if angiogenesis and hypoxia can detect cancer. We used continuous-wave near-infrared spectroscopy (NIRS) to measure blood hemoglobin concentration to obtain blood volume or total hemoglobin [Hbtot] and oxygen saturation for the angiogenesis and hypoxic biomarkers. The contralateral breast was used as a reference to derive the difference from breast tumor as a difference in total hemoglobin Δ[HBtot] and a difference in deoxygenation Δ([Hb]-[HbO2]). A total of 91 invasive cancers, 26 DCIS, 45 fibroblastomas, 96 benign tumors excluding cysts, and 67 normal breasts were examined from four hospitals. In larger-size tumors, there is significantly higher deoxygenation in invasive and ductal carcinoma in situ (DCIS) than in that of benign tumors, but no significant difference was seen in smaller tumors of ≤ 1 cm. With the two parameters of high total hemoglobin and hypoxia score, the sensitivity and specificity of cancer detection were 60.3 % and 85.3 %, respectively. In summary, smaller-size tumors are difficult to detect with NIRS, whereas DCIS can be detected by the same total hemoglobin and hypoxic score in our study.

原文English
頁(從 - 到)211-219
頁數9
期刊Advances in Experimental Medicine and Biology
789
DOIs
出版狀態Published - 2013

指紋

Carcinoma, Intraductal, Noninfiltrating
Near infrared spectroscopy
Near-Infrared Spectroscopy
Tumors
Breast Neoplasms
Hemoglobins
Neoplasms
Blood
Bearings (structural)
Breast
Biopsy
Biomarkers
Hypoxia
Blood Volume
Oxygen
Cysts
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

引用此文

Nioka, S., Shnall, M., Conant, E., Wang, S. C., Reynolds, V. B., Ching, B. C., ... Chance, B. (2013). Breast cancer detection of large size to DCIS by hypoxia and angiogenesis using NIRS. Advances in Experimental Medicine and Biology, 789, 211-219. https://doi.org/10.1007/978-1-4614-7411-1-29
Nioka, Shoko ; Shnall, Mitch ; Conant, Emily ; Wang, Shih Chang ; Reynolds, Visjna Baksa ; Ching, Boon Chye ; Swan, Juliana Ho Teng ; Chung, Pau Choo ; Cheng, Lili ; Shieh, Darbin ; Lin, Yungchi ; Chung, Chenghung ; Tseng, Sheng Hao ; Chance, Britton. / Breast cancer detection of large size to DCIS by hypoxia and angiogenesis using NIRS. 於: Advances in Experimental Medicine and Biology. 2013 ; 卷 789. 頁 211-219.
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abstract = "This investigation aimed to test all tumor-bearing patients who undergo biopsy to see if angiogenesis and hypoxia can detect cancer. We used continuous-wave near-infrared spectroscopy (NIRS) to measure blood hemoglobin concentration to obtain blood volume or total hemoglobin [Hbtot] and oxygen saturation for the angiogenesis and hypoxic biomarkers. The contralateral breast was used as a reference to derive the difference from breast tumor as a difference in total hemoglobin Δ[HBtot] and a difference in deoxygenation Δ([Hb]-[HbO2]). A total of 91 invasive cancers, 26 DCIS, 45 fibroblastomas, 96 benign tumors excluding cysts, and 67 normal breasts were examined from four hospitals. In larger-size tumors, there is significantly higher deoxygenation in invasive and ductal carcinoma in situ (DCIS) than in that of benign tumors, but no significant difference was seen in smaller tumors of ≤ 1 cm. With the two parameters of high total hemoglobin and hypoxia score, the sensitivity and specificity of cancer detection were 60.3 {\%} and 85.3 {\%}, respectively. In summary, smaller-size tumors are difficult to detect with NIRS, whereas DCIS can be detected by the same total hemoglobin and hypoxic score in our study.",
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Breast cancer detection of large size to DCIS by hypoxia and angiogenesis using NIRS. / Nioka, Shoko; Shnall, Mitch; Conant, Emily; Wang, Shih Chang; Reynolds, Visjna Baksa; Ching, Boon Chye; Swan, Juliana Ho Teng; Chung, Pau Choo; Cheng, Lili; Shieh, Darbin; Lin, Yungchi; Chung, Chenghung; Tseng, Sheng Hao; Chance, Britton.

於: Advances in Experimental Medicine and Biology, 卷 789, 2013, p. 211-219.

研究成果: Article

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T1 - Breast cancer detection of large size to DCIS by hypoxia and angiogenesis using NIRS

AU - Nioka, Shoko

AU - Shnall, Mitch

AU - Conant, Emily

AU - Wang, Shih Chang

AU - Reynolds, Visjna Baksa

AU - Ching, Boon Chye

AU - Swan, Juliana Ho Teng

AU - Chung, Pau Choo

AU - Cheng, Lili

AU - Shieh, Darbin

AU - Lin, Yungchi

AU - Chung, Chenghung

AU - Tseng, Sheng Hao

AU - Chance, Britton

PY - 2013

Y1 - 2013

N2 - This investigation aimed to test all tumor-bearing patients who undergo biopsy to see if angiogenesis and hypoxia can detect cancer. We used continuous-wave near-infrared spectroscopy (NIRS) to measure blood hemoglobin concentration to obtain blood volume or total hemoglobin [Hbtot] and oxygen saturation for the angiogenesis and hypoxic biomarkers. The contralateral breast was used as a reference to derive the difference from breast tumor as a difference in total hemoglobin Δ[HBtot] and a difference in deoxygenation Δ([Hb]-[HbO2]). A total of 91 invasive cancers, 26 DCIS, 45 fibroblastomas, 96 benign tumors excluding cysts, and 67 normal breasts were examined from four hospitals. In larger-size tumors, there is significantly higher deoxygenation in invasive and ductal carcinoma in situ (DCIS) than in that of benign tumors, but no significant difference was seen in smaller tumors of ≤ 1 cm. With the two parameters of high total hemoglobin and hypoxia score, the sensitivity and specificity of cancer detection were 60.3 % and 85.3 %, respectively. In summary, smaller-size tumors are difficult to detect with NIRS, whereas DCIS can be detected by the same total hemoglobin and hypoxic score in our study.

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