TY - JOUR
T1 - Budesonide/formoterol anti-inflammatory reliever and maintenance or fluticasone propionate/ salmeterol plus as-needed, short-acting β2 agonist
T2 - Real-world effectiveness in patients without optimally controlled asthma (react) study
AU - Cheng, Shih Lung
AU - Ho, Ming Lin
AU - Lai, Yun Fa
AU - Wang, Hao Chien
AU - Hsu, Jeng Yuan
AU - Liu, Shih Feng
AU - Huang, Ming Shyang
AU - Lee, Cheng Hung
AU - Lin, Ching Hsiung
AU - Hang, Liang Wen
AU - Liu, Yu Chih
AU - Yang, Kuang Yao
AU - Wang, Jia Horng
N1 - Funding Information:
Medical writing and/or editorial assistance in the form of assembling tables, collating author comments, copyediting, fact checking, and referencing based on authors’ detailed directions, was provided by V idula Bhole, MD, MHSc, Shruti Baijal Ph.D. and Maribeth Bogush, MCI, PhD of Cactus Communications. This assistance was funded by AstraZeneca T aiwan. The authors retained full control of the manuscript content.
Publisher Copyright:
© 2020 Cheng et al.
PY - 2020
Y1 - 2020
N2 - Introduction: In the prospective, observational, 16-week REACT study conducted between October 21, 2008 and May 12, 2011, we compared the real-world effectiveness of anti-inflammatory reliever and maintenance therapy with budesonide/formoterol (Symbicort® Turbuhaler) and maintenance therapy with fixed-dose fluticasone/salmeterol (Seretide®) plus as-needed, short-acting β2 agonists (SABAs) in Taiwanese patients with inadequate asthma control. Methods: Asthma control was assessed using the five-item Asthma Control Questionnaire (ACQ-5) and standardized pulmonary function testing. Assessments were performed at baseline and at weeks 4–5 and 12–16. Overall, we enrolled 842 patients at 11 clinics, 723 of whom were included in analyses (budesonide/formoterol, 563.3±1.3 μg/d, n=551; flutica-sone/salmeterol, 1013.8±1.4 μg/d, n=172). Results: At baseline, 72.5% and 27.5% of all patients had “partly” and “uncontrolled” asthma, respectively. Mean±SD ACQ-5 scores were 1.54±1.06 and 1.46±1.28 in the bude-sonide/formoterol and fluticasone/salmeterol groups, respectively. ACQ-5 scores significantly improved from baseline (ie, decreased) in both groups at weeks 4 and 16. ACQ-5 difference scores were significantly lower in the budesonide/formoterol group (−0.91±1.11) than the fluticasone/salmeterol group (−0.69±1.27) at the end of the study (p=0.027). Peak expiratory flow rate significantly improved from baseline in the budesonide/formoterol but not the fluticasone/salmeterol group at the end of the study. Severe exacerbation rates and medical resource utilization were comparable between the budesonide/formoterol and fluti-casone/salmeterol groups. Conclusion: Collectively, results indicate the real-world effectiveness of budesonide/for-moterol anti-inflammatory reliever and maintenance therapy is better than fixed-dose fluti-casone/salmeterol plus as-needed SABA. Trial Registration: ClinicalTrials.gov registration number: NCT00784953.
AB - Introduction: In the prospective, observational, 16-week REACT study conducted between October 21, 2008 and May 12, 2011, we compared the real-world effectiveness of anti-inflammatory reliever and maintenance therapy with budesonide/formoterol (Symbicort® Turbuhaler) and maintenance therapy with fixed-dose fluticasone/salmeterol (Seretide®) plus as-needed, short-acting β2 agonists (SABAs) in Taiwanese patients with inadequate asthma control. Methods: Asthma control was assessed using the five-item Asthma Control Questionnaire (ACQ-5) and standardized pulmonary function testing. Assessments were performed at baseline and at weeks 4–5 and 12–16. Overall, we enrolled 842 patients at 11 clinics, 723 of whom were included in analyses (budesonide/formoterol, 563.3±1.3 μg/d, n=551; flutica-sone/salmeterol, 1013.8±1.4 μg/d, n=172). Results: At baseline, 72.5% and 27.5% of all patients had “partly” and “uncontrolled” asthma, respectively. Mean±SD ACQ-5 scores were 1.54±1.06 and 1.46±1.28 in the bude-sonide/formoterol and fluticasone/salmeterol groups, respectively. ACQ-5 scores significantly improved from baseline (ie, decreased) in both groups at weeks 4 and 16. ACQ-5 difference scores were significantly lower in the budesonide/formoterol group (−0.91±1.11) than the fluticasone/salmeterol group (−0.69±1.27) at the end of the study (p=0.027). Peak expiratory flow rate significantly improved from baseline in the budesonide/formoterol but not the fluticasone/salmeterol group at the end of the study. Severe exacerbation rates and medical resource utilization were comparable between the budesonide/formoterol and fluti-casone/salmeterol groups. Conclusion: Collectively, results indicate the real-world effectiveness of budesonide/for-moterol anti-inflammatory reliever and maintenance therapy is better than fixed-dose fluti-casone/salmeterol plus as-needed SABA. Trial Registration: ClinicalTrials.gov registration number: NCT00784953.
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U2 - 10.2147/DDDT.S266177
DO - 10.2147/DDDT.S266177
M3 - Article
C2 - 33324041
AN - SCOPUS:85097795524
VL - 14
SP - 5441
EP - 5450
JO - Drug Design, Development and Therapy
JF - Drug Design, Development and Therapy
SN - 1177-8881
ER -