Building a functional artery: issues from the perspective of mechanics.

Rudolph L. Gleason, Jin Jia Hu, Jay D. Humphrey

研究成果: Review article

16 引文 斯高帕斯(Scopus)

摘要

Despite the many successes of arterial tissue engineering, clinically viable implants may be a decade or more away. Fortunately, there is much more that we can learn from native vessels with regard to designing for optimal structure, function, and properties. Herein, we examine recent observations in vascular biology from the perspective of nonlinear mechanics. Moreover, we use a constrained mixture model to study potential contributions of individual wall constituents. In both cases, the unique biological and mechanical roles of elastin come to the forefront, especially its role in generating and modulating residual stress within the wall, which appears to be key to multiple growth and remodeling responses.

原文English
頁(從 - 到)2045-2055
頁數11
期刊Frontiers in bioscience : a journal and virtual library
9
DOIs
出版狀態Published - 2004 九月 1

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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