Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study

Adrian J. Green, Cathrine Hoyo, Carolyn J. Mattingly, Yiwen Luo, Jung Ying Tzeng, Susan K. Murphy, David B. Buchwalter, Antonio Planchart

研究成果: Article同行評審

35 引文 斯高帕斯(Scopus)

摘要

Objective: Human obesity is a complex metabolic disorder disproportionately affecting people of lower socioeconomic strata, and ethnic minorities, especially African Americans and Hispanics. Although genetic predisposition and a positive energy balance are implicated in obesity, these factors alone do not account for the excess prevalence of obesity in lower socioeconomic populations. Therefore, environmental factors, including exposure to pesticides, heavy metals, and other contaminants, are agents widely suspected to have obesogenic activity, and they also are spatially correlated with lower socioeconomic status. Our study investigates the causal relationship between exposure to the heavy metal, cadmium (Cd), and obesity in a cohort of children and in a zebrafish model of adipogenesis. Design: An extensive collection of first trimester maternal blood samples obtained as part of the Newborn Epigenetics Study (NEST) was analyzed for the presence of Cd, and these results were cross analyzed with the weight-gain trajectory of the children through age 5 years. Next, the role of Cd as a potential obesogen was analyzed in an in vivo zebrafish model. Results: Our analysis indicates that the presence of Cd in maternal blood during pregnancy is associated with increased risk of juvenile obesity in the offspring, independent of other variables, including lead (Pb) and smoking status. Our results are recapitulated in a zebrafish model, in which exposure to Cd at levels approximating those observed in the NEST study is associated with increased adiposity. Conclusion: Our findings identify Cd as a potential human obesogen. Moreover, these observations are recapitulated in a zebrafish model, suggesting that the underlying mechanisms may be evolutionarily conserved, and that zebrafish may be a valuable model for uncovering pathways leading to Cd-mediated obesity in human populations.

原文English
頁(從 - 到)1285-1295
頁數11
期刊International Journal of Obesity
42
發行號7
DOIs
出版狀態Published - 2018 7月 1

All Science Journal Classification (ASJC) codes

  • 醫藥(雜項)
  • 內分泌學、糖尿病和代謝
  • 營養與營養學

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