Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus

Shwu Jen Wu; Yann Lii Leu; Chou Hsiung Chen; Chih Hua Chao; De Yang Shen; Hsiu Hui Chan; E. Jian Lee; Tian Shung Wu; Yea Hwey Wang; Yuh Chiang Shen; Keduo Qian; Kenneth F. Bastow; Kuo Hsiung Lee

doi:10.1021/np1002143

Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus

Shwu Jen Wu, Yann Lii Leu, Chou Hsiung Chen, Chih Hua Chao, De Yang Shen, Hsiu Hui Chan, E. Jian Lee, Tian Shung Wu, Yea Hwey Wang, Yuh Chiang Shen, Keduo Qian, Kenneth F. Bastow, Kuo Hsiung Lee

研究成果: Article › 同行評審

43 引文斯高帕斯（Scopus）

摘要

Ten new triterpenoids, camphoratins A-J (1-10), along with 12 known compounds were isolated from the fruiting body of Taiwanofungus camphoratus. Their structures were established by spectroscopic analysis and chemical methods. Compound 10 is the first example of a naturally occurring ergosteroid with an unusual cis-C/D ring junction. Compounds 2-6 and 11 showed moderate to potent cytotoxicity, with EC₅₀ values ranging from 0.3 to 3 μM against KB and KB-VIN human cancer cell lines. Compounds 6, 10, 11, 14-16, 18, and 21 exhibited anti-inflammatory NO-production inhibition activity with IC₅₀ values of less than 5 μM, and were more potent than the nonspecific NOS inhibitor N^ω-nitro-l-arginine methyl ester.

原文	English
頁（從 - 到）	1756-1762
頁數	7
期刊	Journal of Natural Products
卷	73
發行號	11
DOIs	https://doi.org/10.1021/np1002143
出版狀態	Published - 2010 11月 29

All Science Journal Classification (ASJC) codes

分析化學
分子醫學
藥理
藥學科學
藥物發現
補充和替代醫學
有機化學

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10.1021/np1002143

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Wu, S. J., Leu, Y. L., Chen, C. H., Chao, C. H., Shen, D. Y., Chan, H. H., Lee, E. J., Wu, T. S., Wang, Y. H., Shen, Y. C., Qian, K., Bastow, K. F., & Lee, K. H. (2010). Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus. Journal of Natural Products, 73(11), 1756-1762. https://doi.org/10.1021/np1002143

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abstract = "Ten new triterpenoids, camphoratins A-J (1-10), along with 12 known compounds were isolated from the fruiting body of Taiwanofungus camphoratus. Their structures were established by spectroscopic analysis and chemical methods. Compound 10 is the first example of a naturally occurring ergosteroid with an unusual cis-C/D ring junction. Compounds 2-6 and 11 showed moderate to potent cytotoxicity, with EC50 values ranging from 0.3 to 3 μM against KB and KB-VIN human cancer cell lines. Compounds 6, 10, 11, 14-16, 18, and 21 exhibited anti-inflammatory NO-production inhibition activity with IC50 values of less than 5 μM, and were more potent than the nonspecific NOS inhibitor Nω-nitro-l-arginine methyl ester.",

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AU - Chao, Chih Hua

AU - Shen, De Yang

AU - Chan, Hsiu Hui

AU - Lee, E. Jian

AU - Wu, Tian Shung

AU - Wang, Yea Hwey

AU - Shen, Yuh Chiang

AU - Qian, Keduo

AU - Bastow, Kenneth F.

AU - Lee, Kuo Hsiung

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AB - Ten new triterpenoids, camphoratins A-J (1-10), along with 12 known compounds were isolated from the fruiting body of Taiwanofungus camphoratus. Their structures were established by spectroscopic analysis and chemical methods. Compound 10 is the first example of a naturally occurring ergosteroid with an unusual cis-C/D ring junction. Compounds 2-6 and 11 showed moderate to potent cytotoxicity, with EC50 values ranging from 0.3 to 3 μM against KB and KB-VIN human cancer cell lines. Compounds 6, 10, 11, 14-16, 18, and 21 exhibited anti-inflammatory NO-production inhibition activity with IC50 values of less than 5 μM, and were more potent than the nonspecific NOS inhibitor Nω-nitro-l-arginine methyl ester.

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Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus

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