Cancellation of low-frequency stimulation-induced long-term depression by docosahexaenoic acid in the rat hippocampus

Chainllie Young, Po-Wu Gean, Shang Peng Wu, Chih Hung Lin, Yu Zen Shen

研究成果: Article

32 引文 斯高帕斯(Scopus)

摘要

The effects of docosahexaenoic acid (DHA) on low-frequency stimulation (LFS)-induced long-term depression (LTD) were investigated in the CA 1 subfield of rat hippocampal slices. LTD was routinely produced by LFS of 900 pulses at 1 Hz. The field excitatory postsynaptic potential (fEPSP) 40 min after LFS was 59 ± 4% (n = 18) of baseline response. However, in experiments from 18 neurons pretreated with DHA (50 μM), fEPSP returned to baseline levels within 20 min after LFS in eight cells and was slightly potentiated in three cells. Only in seven cells was LTD induced. The effect of DHA on LTD was concentration dependent. The slopes of fEPSP 40 min after LFS were 67 ± 4% (n = 6), 72 ± 7% (n = 7) and 80 ± 5% (n = 18) of baseline response, with pretreatment of 1, 10 and 50 μM DHA, respectively. The blockade of LTD induction suggests that DHA may play a role in learning and memory.

原文English
頁(從 - 到)198-200
頁數3
期刊Neuroscience Letters
247
發行號2-3
DOIs
出版狀態Published - 1998 五月 15

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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