Carbohydrate Ligands for COVID-19 Spike Proteins

Yung Kuo Lee, Wen Chiu Chang, Ekambaranellore Prakash, Yu Ju Peng, Zhijay Tu, Chun Hung Lin, Pang Hung Hsu, Chuan Fa Chang

研究成果: Article同行評審

摘要

An outbreak of SARS-CoV-2 coronavirus (COVID-19) first detected in Wuhan, China, has created a public health emergency all over the world. The pandemic has caused more than 340 million confirmed cases and 5.57 million deaths as of 23 January 2022. Although carbohydrates have been found to play a role in coronavirus binding and infection, the role of cell surface glycans in SARS-CoV-2 infection and pathogenesis is still not understood. Herein, we report that the SARS-CoV-2 spike protein S1 subunit binds specifically to blood group A and B antigens, and that the spike protein S2 subunit has a binding preference for Lea antigens. Further examination of the binding preference for different types of red blood cells (RBCs) indicated that the spike protein S1 sub-unit preferentially binds with blood group A RBCs, whereas the spike protein S2 subunit prefers to interact with blood group Lea RBCs. Angiotensin converting enzyme 2 (ACE2), a known target of SARS-CoV-2 spike proteins, was identified to be a blood group A antigen-containing glycoprotein. Additionally, 6-sulfo N-acetyllactosamine was found to inhibit the binding of the spike protein S1 subunit with blood group A RBCs and reduce the interaction between the spike protein S1 subunit and ACE2.

原文English
文章編號330
期刊Viruses
14
發行號2
DOIs
出版狀態Published - 2022 2月

All Science Journal Classification (ASJC) codes

  • 傳染性疾病
  • 病毒學

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