Carteraol E, a potent polyhydroxyl ichthyotoxin from the dinoflagellate Amphidinium carterae

Shin Jong Huang, Chih Ming Kuo, Ying Chih Lin, Yi Min Chen, Chung Kuang Lu

研究成果: Article同行評審

39 引文 斯高帕斯(Scopus)

摘要

Carteraol E (1), C74H126O24, a polyhydroxyl ichthyotoxin, was isolated from the lab-cultured marine dinoflagellate Amphidinium carterae. Carteraol E possessed three tetrahydropyrans, and 19 hydroxyl groups on a C69-linear aliphatic chain with a ketone moiety, an exo-methylene, and three methyl branches. The structure was elucidated by extensive analyses of 2D NMR spectra. Cateraol E exhibited potent ichthyotoxicity with LD50 value of 0.28 μM, and antifungal activity against Aspergillus niger.

原文English
頁(從 - 到)2512-2515
頁數4
期刊Tetrahedron Letters
50
發行號21
DOIs
出版狀態Published - 2009 五月 27

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 藥物發現
  • 有機化學

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