Carteraol E, a potent polyhydroxyl ichthyotoxin from the dinoflagellate Amphidinium carterae

Shin Jong Huang, Chih Ming Kuo, Ying Chih Lin, Yi Min Chen, Chung Kuang Lu

研究成果: Article

32 引文 (Scopus)

摘要

Carteraol E (1), C74H126O24, a polyhydroxyl ichthyotoxin, was isolated from the lab-cultured marine dinoflagellate Amphidinium carterae. Carteraol E possessed three tetrahydropyrans, and 19 hydroxyl groups on a C69-linear aliphatic chain with a ketone moiety, an exo-methylene, and three methyl branches. The structure was elucidated by extensive analyses of 2D NMR spectra. Cateraol E exhibited potent ichthyotoxicity with LD50 value of 0.28 μM, and antifungal activity against Aspergillus niger.

原文English
頁（從 - 到）2512-2515
頁數4
期刊Tetrahedron Letters
卷50
發行號21
DOIs
出版狀態Published - 2009 五月 27

指紋

Dinoflagellida
Aspergillus niger
Aspergillus
Lethal Dose 50
Ketones
Hydroxyl Radical
Nuclear magnetic resonance

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

引用此文

Huang, Shin Jong ; Kuo, Chih Ming ; Lin, Ying Chih ; Chen, Yi Min ; Lu, Chung Kuang. / Carteraol E, a potent polyhydroxyl ichthyotoxin from the dinoflagellate Amphidinium carterae. 於: Tetrahedron Letters. 2009 ; 卷 50, 編號 21. 頁 2512-2515.
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Huang, SJ, Kuo, CM, Lin, YC, Chen, YM & Lu, CK 2009, 'Carteraol E, a potent polyhydroxyl ichthyotoxin from the dinoflagellate Amphidinium carterae', Tetrahedron Letters, 卷 50, 編號 21, 頁 2512-2515. https://doi.org/10.1016/j.tetlet.2009.03.065

Carteraol E, a potent polyhydroxyl ichthyotoxin from the dinoflagellate Amphidinium carterae. / Huang, Shin Jong; Kuo, Chih Ming; Lin, Ying Chih; Chen, Yi Min; Lu, Chung Kuang.

於: Tetrahedron Letters, 卷 50, 編號 21, 27.05.2009, p. 2512-2515.

研究成果: Article

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AU - Lu, Chung Kuang

PY - 2009/5/27

Y1 - 2009/5/27

N2 - Carteraol E (1), C74H126O24, a polyhydroxyl ichthyotoxin, was isolated from the lab-cultured marine dinoflagellate Amphidinium carterae. Carteraol E possessed three tetrahydropyrans, and 19 hydroxyl groups on a C69-linear aliphatic chain with a ketone moiety, an exo-methylene, and three methyl branches. The structure was elucidated by extensive analyses of 2D NMR spectra. Cateraol E exhibited potent ichthyotoxicity with LD50 value of 0.28 μM, and antifungal activity against Aspergillus niger.

AB - Carteraol E (1), C74H126O24, a polyhydroxyl ichthyotoxin, was isolated from the lab-cultured marine dinoflagellate Amphidinium carterae. Carteraol E possessed three tetrahydropyrans, and 19 hydroxyl groups on a C69-linear aliphatic chain with a ketone moiety, an exo-methylene, and three methyl branches. The structure was elucidated by extensive analyses of 2D NMR spectra. Cateraol E exhibited potent ichthyotoxicity with LD50 value of 0.28 μM, and antifungal activity against Aspergillus niger.

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Huang SJ, Kuo CM, Lin YC, Chen YM, Lu CK. Carteraol E, a potent polyhydroxyl ichthyotoxin from the dinoflagellate Amphidinium carterae. Tetrahedron Letters. 2009 5月 27;50(21):2512-2515. https://doi.org/10.1016/j.tetlet.2009.03.065

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