CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells

Chiung Yuan Ko, Ling Hua Chang, Yi Chao Lee, Esta Sterneck, Chun Pei Cheng, Shun-hua Chen, A. Mei Huang, Ta-Chien Tseng, Ju-Ming Wang

研究成果: Article

33 引文 (Scopus)

摘要

The CCAAT/enhancer binding protein delta (CEBPD, C/EBPδ, NF-IL6β) is induced in many inflammation-related diseases, suggesting that CEBPD and its downstream targets may play central roles in these conditions. Neuropathological studies show that a neuroinflammatory response parallels the early stages of Alzheimer's disease (AD). However, the precise mechanistic correlation between inflammation and AD pathogenesis remains unclear. CEBPD is upregulated in the astrocytes of AD patients. Therefore, we asked if activation of astrocytic CEBPD could contribute to AD pathogenesis. In this report, a novel role of CEBPD in attenuating macrophage-mediated phagocytosis of damaged neuron cells was found. By global gene expression profiling, we identified the inflammatory marker pentraxin-3 (PTX3, TNFAIP5, TSG-14) as a CEBPD target in astrocytes. Furthermore, we demonstrate that PTX3 participates in the attenuation of macrophage-mediated phagocytosis of damaged neuron cells. This study provides the first demonstration of a role for astrocytic CEBPD and the CEBPD-regulated molecule PTX3 in the accumulation of damaged neurons, which is a hallmark of ADpathogenesis.

原文English
頁(從 - 到)422.e11-422.e25
期刊Neurobiology of Aging
33
發行號2
DOIs
出版狀態Published - 2012 一月 1

指紋

CCAAT-Enhancer-Binding Protein-delta
Phagocytosis
Macrophages
Neurons
Alzheimer Disease
Astrocytes
CCAAT-Enhancer-Binding Protein-beta
Inflammation
Gene Expression Profiling
Protein C

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

引用此文

Ko, Chiung Yuan ; Chang, Ling Hua ; Lee, Yi Chao ; Sterneck, Esta ; Cheng, Chun Pei ; Chen, Shun-hua ; Huang, A. Mei ; Tseng, Ta-Chien ; Wang, Ju-Ming. / CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells. 於: Neurobiology of Aging. 2012 ; 卷 33, 編號 2. 頁 422.e11-422.e25.
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abstract = "The CCAAT/enhancer binding protein delta (CEBPD, C/EBPδ, NF-IL6β) is induced in many inflammation-related diseases, suggesting that CEBPD and its downstream targets may play central roles in these conditions. Neuropathological studies show that a neuroinflammatory response parallels the early stages of Alzheimer's disease (AD). However, the precise mechanistic correlation between inflammation and AD pathogenesis remains unclear. CEBPD is upregulated in the astrocytes of AD patients. Therefore, we asked if activation of astrocytic CEBPD could contribute to AD pathogenesis. In this report, a novel role of CEBPD in attenuating macrophage-mediated phagocytosis of damaged neuron cells was found. By global gene expression profiling, we identified the inflammatory marker pentraxin-3 (PTX3, TNFAIP5, TSG-14) as a CEBPD target in astrocytes. Furthermore, we demonstrate that PTX3 participates in the attenuation of macrophage-mediated phagocytosis of damaged neuron cells. This study provides the first demonstration of a role for astrocytic CEBPD and the CEBPD-regulated molecule PTX3 in the accumulation of damaged neurons, which is a hallmark of ADpathogenesis.",
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CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells. / Ko, Chiung Yuan; Chang, Ling Hua; Lee, Yi Chao; Sterneck, Esta; Cheng, Chun Pei; Chen, Shun-hua; Huang, A. Mei; Tseng, Ta-Chien; Wang, Ju-Ming.

於: Neurobiology of Aging, 卷 33, 編號 2, 01.01.2012, p. 422.e11-422.e25.

研究成果: Article

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AU - Cheng, Chun Pei

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AU - Huang, A. Mei

AU - Tseng, Ta-Chien

AU - Wang, Ju-Ming

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