CD69 to CD3 ratio of peripheral blood mononuclear cells as a marker to monitor systemic lupus erythematosus disease activity

C. C. Su, W. Y. Shau, C. R. Wang, C. Y. Chuang, C. Y. Chen

研究成果: Article同行評審

31 引文 斯高帕斯(Scopus)

摘要

CD69 is an early T cell activation marker. In order to investigate whether the disease activity of systemic lupus erythematosus (SLE) is correlated with T cell hyperactivity as well as B cell hyperactivity, we measured the CD69 to CD3 ratio (CD69/CD3) of peripheral blood mononuclear cells (PBMCs) from 42 SLE patients and 18 healthy controls. To assess B cell activation, we measured the levels of anti-dsDNA, complement C3 and C4. Disease activity was assessed with the SLE disease activity index (SLEDAI) score. The mean value (± standard deviation) of CD69/CD3 for SLE patients (3.34 ± 0.486) and healthy controls (0.92 ± 0.015) were significantly different 0.05). CD69/CD3, anti-dsDNA, C3 and C4 were all significantly correlated with SLEDAI (r = 0.50, 0.51, -0.68, -0.31, respectively, P < 0.05). CD69/CD3 could explain 25.4% of the variance in SLEDAI, and 6.7% of the valiance that was independent of anti-dsDNA, C3 and C4. In patients with SLEDAI scores which were discordant with anti-dsDNA, C3 and C4 values, CD69/CD3 still showed high correlation with SLEDAI. We conclude that CD69/CD3, which detects T cell activation, is correlated with SLEDAI scores. Thus, T cell activation contributes part of the disease activity independent of B cell activity. This marker can complement in the estimation of disease activity when levels of anti-dsDNA, C3 and C4 fail to show good correlation.

原文English
頁(從 - 到)449-454
頁數6
期刊Lupus
6
發行號5
DOIs
出版狀態Published - 1997 一月 1

All Science Journal Classification (ASJC) codes

  • Rheumatology

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