Cell cycle-dependent regulation of early developmental genes

Hao Jen Huang, Catherine Pears

研究成果: Article同行評審

12 引文 斯高帕斯(Scopus)

摘要

Cell cycle phase at the onset of development in Dictyostelium influences cell fate. Cells in the G2 phase, which tend to become spores, show a more rapid induction of expression of the cell surface receptor involved in the chemotaxis. We show that differential induction of developmental expression is restricted to some transcripts, including those encoding proteins required for chemotaxis, and thus is not due to general transcriptional repression during mitosis. We also show that cells showing rapid induction of one such gene are preferentially located at the centre of early aggregates. These results are consistent with cells derived from G2 phase being at the centre of early aggregates because selective differences in gene regulation render them more efficient at aggregation.

原文English
頁(從 - 到)296-302
頁數7
期刊Biochimica et Biophysica Acta - Molecular Cell Research
1452
發行號3
DOIs
出版狀態Published - 1999 十二月 9

All Science Journal Classification (ASJC) codes

  • 分子生物學
  • 細胞生物學

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